Substance / Medication

Lamotrigine

Overview

Active Ingredient
lamotrigine
RxNorm CUI
28439
Labeler: PD-Rx Pharmaceuticals, Inc.Updated: 2026-02-17T00:00:00.000ZFull label on DailyMed

Indications & Related Conditions

Conditions associated via SNOMED clinical relationships

Administration & Protocol

Dosing, route, and treatment protocol

Detailed dosage and administration information is available in the full FDA drug label.

View full prescribing information on DailyMed

Monitoring & Follow-Up

Biomarkers relevant to this intervention via related conditions

Clinical Trials

91 trials linked to this intervention

91
Total Trials
16
Recruiting
33
With Results

Research Evidence

Published studies and systematic reviews

Sort:
Maternal exposure to lamotrigine and the risk of orofacial clefts in offspring: A systematic review and meta-analysis.
Zhao Ze-Lin, Jin Xiao-Ming, Shi Fang-Ping et al. · Seizure · 2025
PMID: 40513419Meta-Analysis
Rechallenge of Lamotrigine After Rash: A Systematic Review.
Riva Hannah R, Zheng Sabrina, Sohail Nehaa et al. · J Clin Psychiatry · 2025
PMID: 41499178Meta-Analysis
Lithium and lamotrigine for the treatment of bipolar II disorder - a systematic review and meta-analysis of randomized trials.
Fredskild Mette Ungermann, Bruun Caroline Fussing, Vinberg Maj et al. · J Affect Disord · 2025
PMID: 40288449Meta-Analysis
Seizure control and adverse outcomes of lamotrigine use during pregnancy: A systematic review and meta-analysis.
Wan Xin, Wu Yunhong, Zou Qing et al. · Epilepsy Behav · 2024
PMID: 38945077Meta-Analysis
The reference range of lamotrigine in the treatment of epilepsy in children: a systematic review.
Chen Jingjing, Huang Liang, Zeng Linan et al. · Eur J Clin Pharmacol · 2024
PMID: 37906300Meta-AnalysisFull text (PMC)
The efficacy of lamotrigine in bipolar disorder: A systematic review and meta-analysis.
Haenen N, Kamperman A M, Prodan A et al. · Bipolar Disord · 2024
PMID: 38750644Meta-Analysis
Neurodevelopmental outcomes after prenatal exposure to lamotrigine monotherapy in women with epilepsy: a systematic review and meta-analysis.
Peron Audrey, Picot Cyndie, Jurek Lucie et al. · BMC Pregnancy Childbirth · 2024
PMID: 38308208Meta-AnalysisFull text (PMC)
Lamotrigine efficacy, safety, and tolerability for women of childbearing age with bipolar I disorder: Meta-analysis from four randomized, placebo-controlled maintenance studies.
Vieta Eduard, Ghorpade Sanman, Biswas Arunangshu et al. · Eur Neuropsychopharmacol · 2024
PMID: 37775363Meta-Analysis
Dose Monitoring of Lamotrigine Monotherapy in Pregnancy: Are Pregnant Women with Epilepsy Currently Optimally Managed? A Systematic Review.
Goo Yeonkyung, der Nederlanden Anne Marijn, Bleasel Andrew et al. · Ther Drug Monit · 2024
PMID: 38366344Meta-Analysis

Research data from MEDLINE/PubMed

Benefits & Expected Outcomes

Benefits, expected outcomes, efficacy data, and NNT (Number Needed to Treat) are pending physician authorship and evidence review.

Risks & Side Effects

Adverse reaction and safety data for this drug is sourced from the FDA-approved label.

View adverse reactions & drug interactions on DailyMed

Related Symptoms

Symptoms associated with conditions this intervention addresses

No related symptoms have been mapped yet. Symptom linkages are derived through associated conditions.

Alternatives & Comparisons

Alternative treatments, comparison data, and clinical decision support are pending physician authorship.

Medical Disclaimer

This information is for educational purposes only and does not constitute medical advice, diagnosis, or treatment. Always consult with a qualified healthcare provider regarding any medical condition or treatment plan.

Do not start, stop, or change any treatment without consulting your healthcare provider.

Specialists

Providers who commonly manage this intervention

Health Goals

Goals connected through associated conditions

Quick Facts

Type
Substance / Medication
Fully Specified Name
Lamotrigine (substance)
SNOMED CT
387562000
UMLS CUI
C0064636
RxNorm CUI
28439
Labeler
PD-Rx Pharmaceuticals, Inc.

Clinical Data

This intervention maps to 11 entities in the Ltrl knowledge graph.

6
Conditions
3
Biomarkers
1
Specialists
0
Symptoms
91
Clinical Trials

Data is sourced from SNOMED CT, UMLS, and the Ltrl clinical knowledge graph. Content sections marked as pending require physician authorship. Consult a healthcare provider before starting any treatment.