Substance / Medication

Lifitegrast

Overview

Active Ingredient
lifitegrast
RxNorm CUI
1801820

Indications

® Xiidra(lifitegrast ophthalmic solution) 5% is indicated for the treatment of the signs and symptoms of dry eye disease (DED).

Labeler: Novartis Pharmaceuticals CorporationUpdated: 2025-08-18T00:00:00.000ZFull label on DailyMed

Contraindications

When this intervention should not be used

[see Adverse Reactions (6.2)] Xiidra is contraindicated in patients with known hypersensitivity to lifitegrast or to any of the other ingredients in the formulation.

Indications & Related Conditions

Conditions associated via SNOMED clinical relationships

No related conditions have been mapped yet. Condition-intervention linkages are derived from SNOMED CT relationships and will expand as the knowledge graph grows.

Administration & Protocol

Dosing, route, and treatment protocol

Detailed dosage and administration information is available in the full FDA drug label.

View full prescribing information on DailyMed

Monitoring & Follow-Up

Biomarkers relevant to this intervention via related conditions

No monitoring biomarkers have been mapped yet. Biomarker-intervention linkages are derived through related conditions and will expand as the knowledge graph grows.

Research Evidence

Published studies and systematic reviews

Sort:
Efficacy of Lifitegrast Ophthalmic Solution, 5.0%, in Patients With Moderate to Severe Dry Eye Disease: A Post Hoc Analysis of 2 Randomized Clinical Trials.
Holland Edward J, Jackson Mitchell A, Donnenfeld Eric et al. · JAMA Ophthalmol · 2021
PMID: 34617974ObservationalFull text (PMC)
A Clinical Evaluation of Lifitegrast Ophthalmic Solution 5% in Symptomatic Contact Lens Wearers.
Schulze Marc-Matthias, Guthrie Sarah E, Ho Brandon et al. · Clin Ophthalmol · 2025
PMID: 40905028Case ReportFull text (PMC)
Eye amputation following lifitegrast treatment for ocular graft-versus-host disease: First case report.
Ferrete T, Rocher F, Elmaleh V et al. · J Fr Ophtalmol · 2021
PMID: 33858697Case Report
Lifitegrast add-on treatment for dupilumab-induced ocular surface disease (DIOSD): A novel case report.
Zirwas Matthew J, Wulff Katie, Beckman Kenneth · JAAD Case Rep · 2019
PMID: 30555883Case ReportFull text (PMC)
Lifitegrast in Treatment of Dry Eye Disease-A Practical, Narrative Expert Review.
Landsend Erlend C S, Istre Mads, Utheim Tor P · J Ophthalmol · 2025
PMID: 39850608ReviewFull text (PMC)
Safety of lifitegrast: A real-world pharmacovigilance study based on FAERS.
Zhang Chu, Wang Hui, Chen Xianglei et al. · PLoS One · 2025
PMID: 40273175OtherFull text (PMC)

Research data from MEDLINE/PubMed

Benefits & Expected Outcomes

Benefits, expected outcomes, efficacy data, and NNT (Number Needed to Treat) are pending physician authorship and evidence review.

Risks & Side Effects

Adverse reaction and safety data for this drug is sourced from the FDA-approved label.

View adverse reactions & drug interactions on DailyMed

Related Symptoms

Symptoms associated with conditions this intervention addresses

No related symptoms have been mapped yet. Symptom linkages are derived through associated conditions.

Alternatives & Comparisons

Alternative treatments, comparison data, and clinical decision support are pending physician authorship.

Medical Disclaimer

This information is for educational purposes only and does not constitute medical advice, diagnosis, or treatment. Always consult with a qualified healthcare provider regarding any medical condition or treatment plan.

Do not start, stop, or change any treatment without consulting your healthcare provider.

Quick Facts

Type
Substance / Medication
Fully Specified Name
Lifitegrast (substance)
SNOMED CT
720489009
UMLS CUI
C3713860
RxNorm CUI
1801820
Labeler
Novartis Pharmaceuticals Corporation

Clinical Data

This intervention maps to 0 entities in the Ltrl knowledge graph.

0
Conditions
0
Biomarkers
0
Specialists
0
Symptoms

Data is sourced from SNOMED CT, UMLS, and the Ltrl clinical knowledge graph. Content sections marked as pending require physician authorship. Consult a healthcare provider before starting any treatment.