Overview
Indications
Lithium is a mood-stabilizing agent indicated as monotherapy for the treatment of bipolar I disorder: Clinical Studies (14) [see] Treatment of acute manic and mixed episodes in patients 7 years and older Clinical Studies (14) [see] Maintenance treatment in patients 7 years and older
Boxed Warning
FDA Black Box Warning
[see Lithium toxicity is closely related to serum lithium concentrations, and can occur at doses close to therapeutic concentrations. Facilities for prompt and accurate serum lithium determinations should be available before initiating treatment Dosage and Administration (2.3) , Warnings and Precaut
Contraindications
When this intervention should not be used
Adverse Reactions (6) [see]. Lithium is contraindicated in patients with known hypersensitivity to any inactive ingredient in the lithium carbonate capsule
Indications & Related Conditions
Conditions associated via SNOMED clinical relationships
Administration & Protocol
Dosing, route, and treatment protocol
Detailed dosage and administration information is available in the full FDA drug label.
View full prescribing information on DailyMedMonitoring & Follow-Up
Biomarkers relevant to this intervention via related conditions
Clinical Trials
57 trials linked to this intervention
Recent Trials
Continuation Electroconvulsive Therapy Vs Medication to Prevent Relapses in Patients With Major Depressive Disorder
Antidepressant Treatment of Melancholia in Late Life
Studies of Brain Function and Course of Illness in Pediatric Bipolar Disorder
Optimizing Electroconvulsive Therapy for Depression
Ethnic Variations in Antidepressant Response
Research Evidence
Published studies and systematic reviews
Research data from MEDLINE/PubMed
Benefits & Expected Outcomes
Benefits, expected outcomes, efficacy data, and NNT (Number Needed to Treat) are pending physician authorship and evidence review.
Risks & Side Effects
Adverse reaction and safety data for this drug is sourced from the FDA-approved label.
View adverse reactions & drug interactions on DailyMedRelated Symptoms
Symptoms associated with conditions this intervention addresses
No related symptoms have been mapped yet. Symptom linkages are derived through associated conditions.
Alternatives & Comparisons
Alternative treatments, comparison data, and clinical decision support are pending physician authorship.
This information is for educational purposes only and does not constitute medical advice, diagnosis, or treatment. Always consult with a qualified healthcare provider regarding any medical condition or treatment plan.
Do not start, stop, or change any treatment without consulting your healthcare provider.
Specialists
Providers who commonly manage this intervention
Quick Facts
- Type
- Substance / Medication
- Fully Specified Name
- Lithium carbonate (substance)
- SNOMED CT
- 387095003
- UMLS CUI
- C0085217
- RxNorm CUI
- 42351
- Labeler
- American Health Packaging
Clinical Data
This intervention maps to 12 entities in the Ltrl knowledge graph.
Data is sourced from SNOMED CT, UMLS, and the Ltrl clinical knowledge graph. Content sections marked as pending require physician authorship. Consult a healthcare provider before starting any treatment.