Substance / Medication

Loperamide

Overview

Active Ingredient
loperamide
RxNorm CUI
6468

Indications & Related Conditions

Conditions associated via SNOMED clinical relationships

Administration & Protocol

Dosing, route, and treatment protocol

Administration details including route, dosing schedules, preparation instructions, and contraindications are pending physician authorship.

Monitoring & Follow-Up

Biomarkers relevant to this intervention via related conditions

No monitoring biomarkers have been mapped yet. Biomarker-intervention linkages are derived through related conditions and will expand as the knowledge graph grows.

Clinical Trials

7 trials linked to this intervention

7
Total Trials
2
Recruiting
0
With Results

Research Evidence

Published studies and systematic reviews

Sort:
Loperamide therapy for acute diarrhea in children: systematic review and meta-analysis.
Li Su-Ting T, Grossman David C, Cummings Peter · PLoS Med · 2007
PMID: 17388664Meta-AnalysisFull text (PMC)
Evaluation of the Effect of Loperamide on the Cardiac Repolarization Interval Using Exposure-Response Analysis.
Valenzuela Belén, Gisleskog Per Olsson, Cirillo Iolanda et al. · Clin Transl Sci · 2025
PMID: 39866059RCTFull text (PMC)
Morphine Versus Loperamide with Intrasite Gel in the Treatment of Painful Dermal Ulcers: A Randomized, Crossover Study.
Jyothi B, Mitragotri Milon V, Kurugodiyavar Mahesh D et al. · Pain Physician · 2021
PMID: 33400436RCT
The Acute Effect of Loperamide on Ileostomy Output: A Randomized, Double-Blinded, Placebo-Controlled, Crossover Study.
Kristensen Katrine, Qvist Niels · Basic Clin Pharmacol Toxicol · 2017
PMID: 28627732RCT
Loperamide Versus Psyllium Fiber for Treatment of Fecal Incontinence: The Fecal Incontinence Prescription (Rx) Management (FIRM) Randomized Clinical Trial.
Markland Alayne D, Burgio Kathryn L, Whitehead William E et al. · Dis Colon Rectum · 2015
PMID: 26347971RCT
"I just wanted to tell you that loperamide WILL WORK": a web-based study of extra-medical use of loperamide.
Daniulaityte Raminta, Carlson Robert, Falck Russel et al. · Drug Alcohol Depend · 2013
PMID: 23201175RCTFull text (PMC)
Keeping the cecum clean: a randomized, prospective, placebo-controlled trial of loperamide as part of preparation for colonoscopy.
Church James, Bast Jane, Elayi Elodie et al. · Dis Colon Rectum · 2013
PMID: 23222289RCT

Research data from MEDLINE/PubMed

Benefits & Expected Outcomes

Benefits, expected outcomes, efficacy data, and NNT (Number Needed to Treat) are pending physician authorship and evidence review.

Risks & Side Effects

Risk profile, common and serious adverse effects, contraindications, and drug interactions are pending physician authorship.

Related Symptoms

Symptoms associated with conditions this intervention addresses

No related symptoms have been mapped yet. Symptom linkages are derived through associated conditions.

Alternatives & Comparisons

Alternative treatments, comparison data, and clinical decision support are pending physician authorship.

Medical Disclaimer

This information is for educational purposes only and does not constitute medical advice, diagnosis, or treatment. Always consult with a qualified healthcare provider regarding any medical condition or treatment plan.

Do not start, stop, or change any treatment without consulting your healthcare provider.

Quick Facts

Type
Substance / Medication
Fully Specified Name
Loperamide (substance)
SNOMED CT
387040009
UMLS CUI
C0023992
RxNorm CUI
6468

Clinical Data

This intervention maps to 1 entities in the Ltrl knowledge graph.

1
Conditions
0
Biomarkers
0
Specialists
0
Symptoms
7
Clinical Trials

Data is sourced from SNOMED CT, UMLS, and the Ltrl clinical knowledge graph. Content sections marked as pending require physician authorship. Consult a healthcare provider before starting any treatment.