Substance / Medication

Meclofenamate

Overview

Active Ingredient
meclofenamate
RxNorm CUI
588003

Indications & Related Conditions

Conditions associated via SNOMED clinical relationships

Administration & Protocol

Dosing, route, and treatment protocol

Administration details including route, dosing schedules, preparation instructions, and contraindications are pending physician authorship.

Monitoring & Follow-Up

Biomarkers relevant to this intervention via related conditions

No monitoring biomarkers have been mapped yet. Biomarker-intervention linkages are derived through related conditions and will expand as the knowledge graph grows.

Clinical Trials

25 trials linked to this intervention

25
Total Trials
7
Recruiting
13
With Results

Research Evidence

Published studies and systematic reviews

Sort:
Inhibition of Ca-activated chloride channels by the NSAID meclofenamate for anti-diarrhea.
Li Qinqin, Shi Huan, Zhou Ping et al. · Biochem Pharmacol · 2026
PMID: 41544862Other
The nonsteroidal anti-inflammatory drug meclofenamate mitigates kainic acid-induced seizures via TRPM4 inhibition.
Kövesdi Erzsébet, Mundrucz Laura, Gyéresi Attila et al. · Brain Commun · 2025
PMID: 40574972OtherFull text (PMC)
Meclofenamate causes loss of cellular tethering and decoupling of functional networks in glioblastoma.
Schneider Matthias, Vollmer Lea, Potthoff Anna-Laura et al. · Neuro Oncol · 2021
PMID: 33864086OtherFull text (PMC)
Significance of Multiple Bioactivation Pathways for Meclofenamate as Revealed through Modeling and Reaction Kinetics.
Schleiff Mary Alexandra, Flynn Noah R, Payakachat Sasin et al. · Drug Metab Dispos · 2021
PMID: 33239334OtherFull text (PMC)
TRPM4 inhibition by meclofenamate suppresses Ca2+-dependent triggered arrhythmias.
Vandewiele Frone, Pironet Andy, Jacobs Griet et al. · Eur Heart J · 2022
PMID: 35822895Preclinical
Copper(II) complexes with meclofenamate ligands: Structure, interaction with DNA and albumins, antioxidant and anticholinergic activity.
Barmpa Amalia, Hatzidimitriou Antonios G, Psomas George · J Inorg Biochem · 2021
PMID: 33556771Preclinical
Nickel(II)-meclofenamate complexes: Structure, in vitro and in silico DNA- and albumin-binding studies, antioxidant and anticholinergic activity.
Barmpa Amalia, Geromichalos George D, Hatzidimitriou Antonios G et al. · J Inorg Biochem · 2021
PMID: 34139455Preclinical
Different effects of the nonsteroidal anti-inflammatory drugs meclofenamate sodium and naproxen sodium on proteasome activity in cardiac cells.
Ghosh Rajeshwary, Hwang Soyun M, Cui Ziyou et al. · J Mol Cell Cardiol · 2016
PMID: 27049794Preclinical

Research data from MEDLINE/PubMed

Benefits & Expected Outcomes

Benefits, expected outcomes, efficacy data, and NNT (Number Needed to Treat) are pending physician authorship and evidence review.

Risks & Side Effects

Risk profile, common and serious adverse effects, contraindications, and drug interactions are pending physician authorship.

Related Symptoms

Symptoms associated with conditions this intervention addresses

No related symptoms have been mapped yet. Symptom linkages are derived through associated conditions.

Alternatives & Comparisons

Alternative treatments, comparison data, and clinical decision support are pending physician authorship.

Medical Disclaimer

This information is for educational purposes only and does not constitute medical advice, diagnosis, or treatment. Always consult with a qualified healthcare provider regarding any medical condition or treatment plan.

Do not start, stop, or change any treatment without consulting your healthcare provider.

Quick Facts

Type
Substance / Medication
Fully Specified Name
Meclofenamate (substance)
SNOMED CT
117178002
UMLS CUI
C1289957
RxNorm CUI
588003

Clinical Data

This intervention maps to 6 entities in the Ltrl knowledge graph.

6
Conditions
0
Biomarkers
0
Specialists
0
Symptoms
25
Clinical Trials

Data is sourced from SNOMED CT, UMLS, and the Ltrl clinical knowledge graph. Content sections marked as pending require physician authorship. Consult a healthcare provider before starting any treatment.