Substance / Medication

Melatonin

Overview

Active Ingredient
melatonin
RxNorm CUI
6711

Indications & Related Conditions

Conditions associated via SNOMED clinical relationships

Administration & Protocol

Dosing, route, and treatment protocol

Administration details including route, dosing schedules, preparation instructions, and contraindications are pending physician authorship.

Monitoring & Follow-Up

Biomarkers relevant to this intervention via related conditions

No monitoring biomarkers have been mapped yet. Biomarker-intervention linkages are derived through related conditions and will expand as the knowledge graph grows.

Research Evidence

Published studies and systematic reviews

Sort:
Melatonin Use in Young Children: A Systematic Review.
Kracht Chelsea L, Bolamperti Grace, Breeden Rob et al. · JAMA Netw Open · 2026
PMID: 41481289Meta-AnalysisFull text (PMC)
Melatonin supplementation reduces delirium incidence in critically ill patients: a systematic review and meta-analysis.
Wu Xiaoyu, Hu Panxin, Wu Haopeng et al. · Front Pharmacol · 2026
PMID: 41602948Meta-AnalysisFull text (PMC)
The effect of melatonin administration on motor recovery after spinal cord injury in animal models: a systematic review and meta-analysis.
Khodabakhshi Korelaei Ali, Fallahi Arash, Hamblin Michael R et al. · Spinal Cord · 2025
PMID: 39979444Meta-Analysis
Influence of melatonin supplementation on cancer-related fatigue: a meta-analysis of randomized controlled trials.
Li Yongchao, Zhang Wencai, Zeng Xiaochun et al. · Clin Transl Oncol · 2025
PMID: 39733381Meta-Analysis
Melatonin secretion across puberty: A systematic review and meta-analysis.
Andersen Christian C, Kjær Eva K R, Vase Christian B et al. · Psychoneuroendocrinology · 2025
PMID: 39823958Meta-Analysis
The role of melatonin and circadian rhythms in the pathogenesis of diabetic retinopathy: A systematic review.
Senthil Mallika Prem, Devlin Eilish, Hassani Abolfazl et al. · Diabetes Metab Syndr · 2025
PMID: 39933215Meta-Analysis
Impact of Melatonin Supplementation on Glycemic Parameters in Patients with Type 2 Diabetes: A Systematic Review and Meta-analysis.
Abadi Reza Nejad Shahrokh, Jazinaki Mostafa Shahraki, Bahari Hossein et al. · Curr Pharm Des · 2025
PMID: 39428939Meta-Analysis
Efficacy of melatonin for treatment and prevention of neonatal necrotizing enterocolitis: a systematic review.
Elgenidy Anas, Atef Abdelsattar Ibrahim Hoda, Elmozugi Taher et al. · Naunyn Schmiedebergs Arch Pharmacol · 2025
PMID: 39708100Meta-Analysis
Efficacy of melatonin vs. midazolam for oral premedication in children: a systematic review and meta-analysis.
Ponde Vrushali C, Singh Neha, Gursale Anuya et al. · Minerva Pediatr (Torino) · 2025
PMID: 39621359Meta-Analysis

Research data from MEDLINE/PubMed

Benefits & Expected Outcomes

Benefits, expected outcomes, efficacy data, and NNT (Number Needed to Treat) are pending physician authorship and evidence review.

Risks & Side Effects

Risk profile, common and serious adverse effects, contraindications, and drug interactions are pending physician authorship.

Related Symptoms

Symptoms associated with conditions this intervention addresses

No related symptoms have been mapped yet. Symptom linkages are derived through associated conditions.

Alternatives & Comparisons

Alternative treatments, comparison data, and clinical decision support are pending physician authorship.

Medical Disclaimer

This information is for educational purposes only and does not constitute medical advice, diagnosis, or treatment. Always consult with a qualified healthcare provider regarding any medical condition or treatment plan.

Do not start, stop, or change any treatment without consulting your healthcare provider.

Quick Facts

Type
Substance / Medication
Fully Specified Name
Melatonin (substance)
SNOMED CT
41199001
UMLS CUI
C0025219
RxNorm CUI
6711

Clinical Data

This intervention maps to 1 entities in the Ltrl knowledge graph.

1
Conditions
0
Biomarkers
0
Specialists
0
Symptoms

Data is sourced from SNOMED CT, UMLS, and the Ltrl clinical knowledge graph. Content sections marked as pending require physician authorship. Consult a healthcare provider before starting any treatment.