Substance / Medication

Mesalamine

Overview

Active Ingredient
mesalamine
RxNorm CUI
52582

Indications

Mesalamine delayed-release tablets are indicated for the treatment of moderately active ulcerative colitis in adults. Limitations of Use : Safety and effectiveness of mesalamine delayed-release tablets beyond 6 weeks have not been established.

Labeler: AvKAREUpdated: 2026-01-14T00:00:00.000ZFull label on DailyMed

Contraindications

When this intervention should not be used

5.3 6.2 11 [see Warnings and Precautions (), Adverse Reactions (), and Description ()] Mesalamine delayed-release tablets are contraindicated in patients with known or suspected hypersensitivity to salicylates or aminosalicylates or to any of the ingredients of mesalamine delayed-release tablets.

Indications & Related Conditions

Conditions associated via SNOMED clinical relationships

Administration & Protocol

Dosing, route, and treatment protocol

Detailed dosage and administration information is available in the full FDA drug label.

View full prescribing information on DailyMed

Monitoring & Follow-Up

Biomarkers relevant to this intervention via related conditions

No monitoring biomarkers have been mapped yet. Biomarker-intervention linkages are derived through related conditions and will expand as the knowledge graph grows.

Clinical Trials

84 trials linked to this intervention

84
Total Trials
30
Recruiting
15
With Results

Research Evidence

Published studies and systematic reviews

Sort:
Budesonide Versus Mesalamine in Microscopic Colitis: A Comparative Meta-analysis of Randomized Controlled Trials.
Malik Adnan, Goyal Hemant, Adler Douglas G et al. · J Clin Gastroenterol · 2025
PMID: 39042479Meta-Analysis
Systematic Review and Meta-analysis: Efficacy of Mesalamine in Irritable Bowel Syndrome.
Goodoory Vivek C, Tuteja Ashok K, Black Christopher J et al. · Clin Gastroenterol Hepatol · 2024
PMID: 36858143Meta-Analysis
Genetic Background of Mesalamine-induced Fever and Diarrhea in Japanese Patients with Inflammatory Bowel Disease.
Suzuki Kaoru, Kakuta Yoichi, Naito Takeo et al. · Inflamm Bowel Dis · 2022
PMID: 33501934Meta-Analysis
Mesalamine (5-ASA) for the prevention of recurrent diverticulitis.
Carter Flloyd, Alsayb Majd, Marshall John K et al. · Cochrane Database Syst Rev · 2017
PMID: 28973845Meta-AnalysisFull text (PMC)
Mesalamine Does Not Help Prevent Recurrent Acute Colonic Diverticulitis: Meta-Analysis of Randomized, Placebo-Controlled Trials.
Khan Muhammad Ali, Ali Bilal, Lee Wade M et al. · Am J Gastroenterol · 2016
PMID: 27125717Meta-Analysis
Long-Term Benefit of Mesalamine Granules for Patients Who Achieved Corticosteroid-Induced Ulcerative Colitis Remission.
Lichtenstein Gary R, Gordon Glenn L, Zakko Salam et al. · Dig Dis Sci · 2016
PMID: 26563167Meta-AnalysisFull text (PMC)
MMX mesalamine: a novel high-dose, once-daily 5-aminosalicylate formulation for the treatment of ulcerative colitis.
Hu Mary Y, Peppercorn Mark A · Expert Opin Pharmacother · 2008
PMID: 18377346Meta-Analysis
Mesalamine and relapse prevention in Crohn's disease.
Cottone M, Cammà C · Gastroenterology · 2000
PMID: 10960274Meta-Analysis

Research data from MEDLINE/PubMed

Benefits & Expected Outcomes

Benefits, expected outcomes, efficacy data, and NNT (Number Needed to Treat) are pending physician authorship and evidence review.

Risks & Side Effects

Adverse reaction and safety data for this drug is sourced from the FDA-approved label.

View adverse reactions & drug interactions on DailyMed

Related Symptoms

Symptoms associated with conditions this intervention addresses

No related symptoms have been mapped yet. Symptom linkages are derived through associated conditions.

Alternatives & Comparisons

Alternative treatments, comparison data, and clinical decision support are pending physician authorship.

Medical Disclaimer

This information is for educational purposes only and does not constitute medical advice, diagnosis, or treatment. Always consult with a qualified healthcare provider regarding any medical condition or treatment plan.

Do not start, stop, or change any treatment without consulting your healthcare provider.

Quick Facts

Type
Substance / Medication
Fully Specified Name
Mesalazine (substance)
SNOMED CT
387501005
UMLS CUI
C0127615
RxNorm CUI
52582
Labeler
AvKARE

Clinical Data

This intervention maps to 2 entities in the Ltrl knowledge graph.

2
Conditions
0
Biomarkers
0
Specialists
0
Symptoms
84
Clinical Trials

Data is sourced from SNOMED CT, UMLS, and the Ltrl clinical knowledge graph. Content sections marked as pending require physician authorship. Consult a healthcare provider before starting any treatment.