Substance / Medication

Metaxalone

Overview

Active Ingredient
metaxalone
RxNorm CUI
59078

Indications

Metaxalone tablets are indicated as an adjunct to rest, physical therapy, and other measures for the relief of discomfort associated with acute, painful musculoskeletal conditions in adults and pediatric patients 13 years of age and older.

Labeler: Sportpharm LLCUpdated: 2026-02-03T00:00:00.000ZFull label on DailyMed

Contraindications

When this intervention should not be used

Metaxalone tablets are contraindicated in patients with: Known hypersensitivity to any component of metaxalone tablets. Known tendency to drug induced, hemolytic, or other anemias. Severe renal or hepatic impairment.

Indications & Related Conditions

Conditions associated via SNOMED clinical relationships

Administration & Protocol

Dosing, route, and treatment protocol

Detailed dosage and administration information is available in the full FDA drug label.

View full prescribing information on DailyMed

Monitoring & Follow-Up

Biomarkers relevant to this intervention via related conditions

No monitoring biomarkers have been mapped yet. Biomarker-intervention linkages are derived through related conditions and will expand as the knowledge graph grows.

Clinical Trials

3 trials linked to this intervention

3
Total Trials
1
Recruiting
1
With Results

Research Evidence

Published studies and systematic reviews

Sort:
A Randomized, Placebo-Controlled Trial of Ibuprofen Plus Metaxalone, Tizanidine, or Baclofen for Acute Low Back Pain.
Friedman Benjamin W, Irizarry Eddie, Solorzano Clemencia et al. · Ann Emerg Med · 2019
PMID: 30955985ObservationalFull text (PMC)
Pediatric metaxalone ingestions reported to Texas poison control centers, 2000-2007.
Forrester Mathias B · Pediatr Emerg Care · 2010
PMID: 20042913Observational
Metaxalone-induced Immune Hemolytic Anemia.
Onyechi Afoma, Ohemeng-Dapaah Jessica, Patel Rushin et al. · J Community Hosp Intern Med Perspect · 2023
PMID: 37868679Case ReportFull text (PMC)
Serotonin syndrome associated with therapeutic metaxalone in a patient with cirrhosis.
Surmaitis Ryan M, Nappe Thomas M, Cook Matthew D · Am J Emerg Med · 2016
PMID: 26159819Case Report
Serotonin syndrome following metaxalone overdose and therapeutic use of a selective serotonin reuptake inhibitor.
Martini Dyllon Ivy, Nacca Nicholas, Haswell David et al. · Clin Toxicol (Phila) · 2015
PMID: 25671244Case Report
A rare fatality attributed solely to metaxalone.
Curtis Byron, Jenkins Charla, Wiens Andrea L · J Anal Toxicol · 2015
PMID: 25673649Case Report
Serotonin syndrome associated with metaxalone overdose.
Bosak Adam R, Skolnik Aaron B · J Med Toxicol · 2014
PMID: 24805103Case ReportFull text (PMC)
A fatality involving metaxalone.
Moore Karla A, Levine Barry, Fowler David · Forensic Sci Int · 2005
PMID: 15749367Case Report
Metaxalone (Skelaxin)-related death.
Poklis Justin L, Ropero-Miller Jeri D, Garside Diana et al. · J Anal Toxicol · 2004
PMID: 15516312Case Report

Research data from MEDLINE/PubMed

Benefits & Expected Outcomes

Benefits, expected outcomes, efficacy data, and NNT (Number Needed to Treat) are pending physician authorship and evidence review.

Risks & Side Effects

Adverse reaction and safety data for this drug is sourced from the FDA-approved label.

View adverse reactions & drug interactions on DailyMed

Related Symptoms

Symptoms associated with conditions this intervention addresses

No related symptoms have been mapped yet. Symptom linkages are derived through associated conditions.

Alternatives & Comparisons

Alternative treatments, comparison data, and clinical decision support are pending physician authorship.

Medical Disclaimer

This information is for educational purposes only and does not constitute medical advice, diagnosis, or treatment. Always consult with a qualified healthcare provider regarding any medical condition or treatment plan.

Do not start, stop, or change any treatment without consulting your healthcare provider.

Quick Facts

Type
Substance / Medication
Fully Specified Name
Metaxalone (substance)
SNOMED CT
87599003
UMLS CUI
C0163055
RxNorm CUI
59078
Labeler
Sportpharm LLC

Clinical Data

This intervention maps to 1 entities in the Ltrl knowledge graph.

1
Conditions
0
Biomarkers
0
Specialists
0
Symptoms
3
Clinical Trials

Data is sourced from SNOMED CT, UMLS, and the Ltrl clinical knowledge graph. Content sections marked as pending require physician authorship. Consult a healthcare provider before starting any treatment.