Substance / Medication

Midodrine

Overview

Active Ingredient
midodrine
RxNorm CUI
6963

Indications & Related Conditions

Conditions associated via SNOMED clinical relationships

Administration & Protocol

Dosing, route, and treatment protocol

Administration details including route, dosing schedules, preparation instructions, and contraindications are pending physician authorship.

Monitoring & Follow-Up

Biomarkers relevant to this intervention via related conditions

No monitoring biomarkers have been mapped yet. Biomarker-intervention linkages are derived through related conditions and will expand as the knowledge graph grows.

Clinical Trials

16 trials linked to this intervention

16
Total Trials
3
Recruiting
8
With Results

Research Evidence

Published studies and systematic reviews

Sort:
Adjunctive Midodrine Therapy for Vasopressor-Dependent Shock in the ICU: A Systematic Review and Meta-Analysis.
Kilcommons Sebastian J, Hammal Fadi, Kamaleldin Mostafa et al. · Crit Care Med · 2025
PMID: 39631091Meta-AnalysisFull text (PMC)
Effect of midodrine on the prognosis of patients with septic shock: a systematic review and meta-analysis.
He Q-F, Xing X-K, Wang T-Q et al. · Eur Rev Med Pharmacol Sci · 2023
PMID: 37203847Meta-Analysis
Utility of Midodrine During the Recovery Phase of Shock: A Systematic Review and Meta-analysis of Randomized Controlled Trials.
Khokher Waleed, Iftikhar Saffa, Beran Azizullah et al. · Am J Ther · 2023
PMID: 37278709Meta-Analysis
Midodrine for the prevention of vasovagal syncope: a systematic review and meta-analysis.
Lei Lucy Y, Raj Satish R, Sheldon Robert S · Europace · 2022
PMID: 35025999Meta-AnalysisFull text (PMC)
Midodrine as an Adjuvant to Intravenous Vasopressor Agents in Adults With Resolving Shock: Systematic Review and Meta-Analysis.
Hammond Drayton A, Smith Melanie N, Peksa Gary D et al. · J Intensive Care Med · 2020
PMID: 31030630Meta-Analysis
Effects of midodrine in patients with ascites due to cirrhosis: Systematic review and meta-analysis.
Guo Ting Ting, Yang Yue, Song Yang et al. · J Dig Dis · 2016
PMID: 26630543Meta-Analysis
Midodrine for orthostatic hypotension and recurrent reflex syncope: A systematic review.
Izcovich Ariel, González Malla Carlos, Manzotti Matias et al. · Neurology · 2014
PMID: 25150287Meta-Analysis
Midodrine for orthostatic hypotension: a systematic review and meta-analysis of clinical trials.
Parsaik Ajay K, Singh Balwinder, Altayar Osama et al. · J Gen Intern Med · 2013
PMID: 23775146Meta-AnalysisFull text (PMC)
Midodrine appears to be safe and effective for dialysis-induced hypotension: a systematic review.
Prakash Suma, Garg Amit X, Heidenheim A Paul et al. · Nephrol Dial Transplant · 2004
PMID: 15280522Meta-Analysis
A randomised trial to assess the impact of midodrine on early mobilisation after elective primary hip replacement surgery.
Cammerman Adam C, Haslam Daniel Wl, Currigan Dale A et al. · Anaesth Intensive Care · 2025
PMID: 39921403RCT

Research data from MEDLINE/PubMed

Benefits & Expected Outcomes

Benefits, expected outcomes, efficacy data, and NNT (Number Needed to Treat) are pending physician authorship and evidence review.

Risks & Side Effects

Risk profile, common and serious adverse effects, contraindications, and drug interactions are pending physician authorship.

Related Symptoms

Symptoms associated with conditions this intervention addresses

No related symptoms have been mapped yet. Symptom linkages are derived through associated conditions.

Alternatives & Comparisons

Alternative treatments, comparison data, and clinical decision support are pending physician authorship.

Medical Disclaimer

This information is for educational purposes only and does not constitute medical advice, diagnosis, or treatment. Always consult with a qualified healthcare provider regarding any medical condition or treatment plan.

Do not start, stop, or change any treatment without consulting your healthcare provider.

Quick Facts

Type
Substance / Medication
Fully Specified Name
Midodrine (substance)
SNOMED CT
372504000
UMLS CUI
C0026078
RxNorm CUI
6963

Clinical Data

This intervention maps to 1 entities in the Ltrl knowledge graph.

1
Conditions
0
Biomarkers
0
Specialists
0
Symptoms
16
Clinical Trials

Data is sourced from SNOMED CT, UMLS, and the Ltrl clinical knowledge graph. Content sections marked as pending require physician authorship. Consult a healthcare provider before starting any treatment.