Back to Interventions
Substance / Medication

Nalmefene

SNOMED 109098006UMLS C0068377

Overview

Active Ingredient
nalmefene
RxNorm CUI
31479

Indications & Related Conditions

Conditions associated via SNOMED clinical relationships

Respiratory disorder

Administration & Protocol

Dosing, route, and treatment protocol

Administration details including route, dosing schedules, preparation instructions, and contraindications are pending physician authorship.

Monitoring & Follow-Up

Biomarkers relevant to this intervention via related conditions

No monitoring biomarkers have been mapped yet. Biomarker-intervention linkages are derived through related conditions and will expand as the knowledge graph grows.

Clinical Trials

2 trials linked to this intervention

2
Total Trials
0
Recruiting
0
With Results

Recent Trials

Effect of Nalmefene on the Quality of Resuscitation in Patients Under General Anesthesia

NCT04713358Phase 4Completed542 enrolled

Treatment of Patients Suffering of Alcohol Dependence and Impaired Liver Function With Selincro® As-needed Use

NCT02197598Phase 4Completed45 enrolled
View all 2 trials on ClinicalTrials.gov

Research Evidence

Published studies and systematic reviews

Sort:
Nalmefene combined noninvasive positive-pressure ventilation in Chinese patients with chronic obstructive pulmonary disease coupled with type II respiratory failure: A meta-analysis.
He Jie, Luo Wei, Mei Yang et al. · Medicine (Baltimore) · 2023
PMID: 37543782Meta-AnalysisFull text (PMC)
[Treatment of borderline personality disorder with opioid antagonists: buprenorphine, nalmefene, naloxone and naltrexone in the treatment of dissociative symptoms, self-mutilation and suicidal behavior].
García María Cecilia · Vertex · 2020
PMID: 33890928Meta-Analysis
Safety of nalmefene for the treatment of alcohol use disorder: an update.
López-Pelayo Hugo, Zuluaga Paola, Caballeria Elsa et al. · Expert Opin Drug Saf · 2020
PMID: 31868031Meta-Analysis
Pharmacologically controlled drinking in the treatment of alcohol dependence or alcohol use disorders: a systematic review with direct and network meta-analyses on nalmefene, naltrexone, acamprosate, baclofen and topiramate.
Palpacuer Clément, Duprez Renan, Huneau Alexandre et al. · Addiction · 2018
PMID: 28940866Meta-Analysis
Harms associated with taking nalmefene for substance use and impulse control disorders: A systematic review and meta-analysis of randomised controlled trials.
Johansen Karina Glies Vincents, Tarp Simon, Astrup Arne et al. · PLoS One · 2017
PMID: 28850596Meta-AnalysisFull text (PMC)
The Cost-Effectiveness of the Integration of Nalmefene within the UK Healthcare System Treatment Pathway for Alcohol Dependence.
Laramée Philippe, Bell Melissa, Irving Adam et al. · Alcohol Alcohol · 2016
PMID: 26825639Meta-Analysis
Nalmefene for the management of alcohol dependence: review on its pharmacology, mechanism of action and meta-analysis on its clinical efficacy.
Mann Karl, Torup Lars, Sørensen Per et al. · Eur Neuropsychopharmacol · 2016
PMID: 27842940Meta-Analysis
Comparing Nalmefene and Naltrexone in Alcohol Dependence: Are there any Differences? Results from an Indirect Meta-analysis - Comment to Naudet.
Soyka M, Friede M, Schnitker J · Pharmacopsychiatry · 2016
PMID: 27388713Meta-Analysis
Clinical relevance of nalmefene versus placebo in alcohol treatment: reduction in mortality risk.
Roerecke Michael, Sørensen Per, Laramée Philippe et al. · J Psychopharmacol · 2015
PMID: 26349557Meta-AnalysisFull text (PMC)
Risks and Benefits of Nalmefene in the Treatment of Adult Alcohol Dependence: A Systematic Literature Review and Meta-Analysis of Published and Unpublished Double-Blind Randomized Controlled Trials.
Palpacuer Clément, Laviolle Bruno, Boussageon Rémy et al. · PLoS Med · 2015
PMID: 26694529Meta-AnalysisFull text (PMC)

Research data from MEDLINE/PubMed

Benefits & Expected Outcomes

Benefits, expected outcomes, efficacy data, and NNT (Number Needed to Treat) are pending physician authorship and evidence review.

Risks & Side Effects

Risk profile, common and serious adverse effects, contraindications, and drug interactions are pending physician authorship.

Related Symptoms

Symptoms associated with conditions this intervention addresses

No related symptoms have been mapped yet. Symptom linkages are derived through associated conditions.

Alternatives & Comparisons

Alternative treatments, comparison data, and clinical decision support are pending physician authorship.

Medical Disclaimer

This information is for educational purposes only and does not constitute medical advice, diagnosis, or treatment. Always consult with a qualified healthcare provider regarding any medical condition or treatment plan.

Do not start, stop, or change any treatment without consulting your healthcare provider.

Quick Facts

Type
Substance / Medication
Fully Specified Name
Nalmefene (substance)
SNOMED CT
109098006
UMLS CUI
C0068377
RxNorm CUI
31479

Clinical Data

This intervention maps to 1 entities in the Ltrl knowledge graph.

1
Conditions
0
Biomarkers
0
Specialists
0
Symptoms
2
Clinical Trials

Data is sourced from SNOMED CT, UMLS, and the Ltrl clinical knowledge graph. Content sections marked as pending require physician authorship. Consult a healthcare provider before starting any treatment.