Substance / Medication

Obiltoxaximab

Overview

Active Ingredient
obiltoxaximab
RxNorm CUI
1746906
Labeler: Elusys Therapeutics, Inc.Updated: 2025-11-17T00:00:00.000ZFull label on DailyMed

Boxed Warning

FDA Black Box Warning

Hypersensitivity and anaphylaxis have been reported during the intravenous infusion of ANTHIM. Due to the risk of hypersensitivity and anaphylaxis, ANTHIM should be administered in monitored settings by personnel trained and equipped to manage anaphylaxis. Monitor individuals who receive ANTHIM clos

Contraindications

When this intervention should not be used

None.

Indications & Related Conditions

Conditions associated via SNOMED clinical relationships

Administration & Protocol

Dosing, route, and treatment protocol

Detailed dosage and administration information is available in the full FDA drug label.

View full prescribing information on DailyMed

Monitoring & Follow-Up

Biomarkers relevant to this intervention via related conditions

No monitoring biomarkers have been mapped yet. Biomarker-intervention linkages are derived through related conditions and will expand as the knowledge graph grows.

Research Evidence

Published studies and systematic reviews

Sort:
Safety, Pharmacokinetics, and Immunogenicity of Obiltoxaximab After Intramuscular Administration to Healthy Humans.
Nagy Christa F, Leach Timothy S, King Alex et al. · Clin Pharmacol Drug Dev · 2018
PMID: 29125719RCTFull text (PMC)
Pharmacokinetics and Tolerability of Obiltoxaximab: A Report of 5 Healthy Volunteer Studies.
Nagy Christa F, Leach Timothy S, Hoffman Joseph H et al. · Clin Ther · 2016
PMID: 27568215Observational
Welder's Anthrax Treated with Obiltoxaximab - Louisiana, 2024.
Thompson Julie M, Lundstrom Eric W, Hein Lindsay D et al. · MMWR Morb Mortal Wkly Rep · 2026
PMID: 41468309Case ReportFull text (PMC)
Obiltoxaximab (Anthim) for inhalation anthrax.
Med Lett Drugs Ther · 2018
PMID: 30383733Review
Obiltoxaximab: Adding to the Treatment Arsenal for Bacillus anthracis Infection.
Hou Audrey W, Morrill Amanda M · Ann Pharmacother · 2017
PMID: 28573869Review
Obiltoxaximab: First Global Approval.
Greig Sarah L · Drugs · 2016
PMID: 27085536Review
Animal-to-Human Dose Translation of Obiltoxaximab for Treatment of Inhalational Anthrax Under the US FDA Animal Rule.
Nagy C F, Mondick J, Serbina N et al. · Clin Transl Sci · 2017
PMID: 27925405PreclinicalFull text (PMC)
Efficacy Projection of Obiltoxaximab for Treatment of Inhalational Anthrax across a Range of Disease Severity.
Yamamoto Brent J, Shadiack Annette M, Carpenter Sarah et al. · Antimicrob Agents Chemother · 2016
PMID: 27431222PreclinicalFull text (PMC)
Obiltoxaximab Prevents Disseminated Bacillus anthracis Infection and Improves Survival during Pre- and Postexposure Prophylaxis in Animal Models of Inhalational Anthrax.
Yamamoto Brent J, Shadiack Annette M, Carpenter Sarah et al. · Antimicrob Agents Chemother · 2016
PMID: 27431219PreclinicalFull text (PMC)

Research data from MEDLINE/PubMed

Benefits & Expected Outcomes

Benefits, expected outcomes, efficacy data, and NNT (Number Needed to Treat) are pending physician authorship and evidence review.

Risks & Side Effects

Adverse reaction and safety data for this drug is sourced from the FDA-approved label.

View adverse reactions & drug interactions on DailyMed

Related Symptoms

Symptoms associated with conditions this intervention addresses

No related symptoms have been mapped yet. Symptom linkages are derived through associated conditions.

Alternatives & Comparisons

Alternative treatments, comparison data, and clinical decision support are pending physician authorship.

Medical Disclaimer

This information is for educational purposes only and does not constitute medical advice, diagnosis, or treatment. Always consult with a qualified healthcare provider regarding any medical condition or treatment plan.

Do not start, stop, or change any treatment without consulting your healthcare provider.

Quick Facts

Type
Substance / Medication
Fully Specified Name
Obiltoxaximab (substance)
SNOMED CT
724038005
UMLS CUI
C4224790
RxNorm CUI
1746906
Labeler
Elusys Therapeutics, Inc.

Clinical Data

This intervention maps to 3 entities in the Ltrl knowledge graph.

3
Conditions
0
Biomarkers
0
Specialists
0
Symptoms

Data is sourced from SNOMED CT, UMLS, and the Ltrl clinical knowledge graph. Content sections marked as pending require physician authorship. Consult a healthcare provider before starting any treatment.