Substance / Medication

Ondansetron

Overview

Active Ingredient
ondansetron
RxNorm CUI
26225

Indications

Ondansetron orally disintegrating tablets are indicated for the prevention of nausea and vomiting associated with: Ondansetron orally disintegrating tablets also indicated for the prevention of postoperative nausea and/or vomiting. 2 highly emetogenic cancer chemotherapy, including cisplatin greater than or equal to 50 mg/m initial and repeat courses of moderately emetogenic cancer chemotherapy radiotherapy in patients receiving either total body irradiation, single high-dose fraction to the abd

Labeler: A-S Medication SolutionsUpdated: 2026-02-18T00:00:00.000ZFull label on DailyMed

Contraindications

When this intervention should not be used

Ondansetron orally disintegrating tablets are contraindicated in patients: Adverse Reactions (6.2) [see] known to have hypersensitivity (e.g., anaphylaxis) to ondansetron or any of the components of the formulation receiving concomitant apomorphine due to the risk of profound hypotension and loss of

Indications & Related Conditions

Conditions associated via SNOMED clinical relationships

Administration & Protocol

Dosing, route, and treatment protocol

Detailed dosage and administration information is available in the full FDA drug label.

View full prescribing information on DailyMed

Monitoring & Follow-Up

Biomarkers relevant to this intervention via related conditions

No monitoring biomarkers have been mapped yet. Biomarker-intervention linkages are derived through related conditions and will expand as the knowledge graph grows.

Clinical Trials

116 trials linked to this intervention

116
Total Trials
19
Recruiting
46
With Results

Research Evidence

Published studies and systematic reviews

Sort:
Effect of ondansetron compared to lidocaine and placebo for reducing propofol injection pain: A systematic review and meta-analysis of randomized controlled trials.
Zaazouee Mohamed Sayed, Mahmoud Abdelrahman Mohamed, Elfar Waleed Hosny et al. · Medicine (Baltimore) · 2023
PMID: 37746949Meta-AnalysisFull text (PMC)
A meta-analysis of randomized controlled trials: efficiency and safety of ondansetron in preventing post-anesthesia shivering during cesarean section.
Zheng Guanghao, Zhang Jieyu, Liu Jianpin et al. · Arch Gynecol Obstet · 2023
PMID: 35325278Meta-Analysis
Randomised, placebo-controlled trial and meta-analysis show benefit of ondansetron for irritable bowel syndrome with diarrhoea: The TRITON trial.
Gunn David, Topan Rabia, Barnard Lorna et al. · Aliment Pharmacol Ther · 2023
PMID: 36866724Meta-Analysis
Risk of abnormal pregnancy outcomes after using ondansetron during pregnancy: A systematic review and meta-analysis.
Cao Xiao, Sun Mingyao, Yang QiuYu et al. · Front Pharmacol · 2022
PMID: 36120333Meta-AnalysisFull text (PMC)

Research data from MEDLINE/PubMed

Benefits & Expected Outcomes

Benefits, expected outcomes, efficacy data, and NNT (Number Needed to Treat) are pending physician authorship and evidence review.

Risks & Side Effects

Adverse reaction and safety data for this drug is sourced from the FDA-approved label.

View adverse reactions & drug interactions on DailyMed

Related Symptoms

Symptoms associated with conditions this intervention addresses

No related symptoms have been mapped yet. Symptom linkages are derived through associated conditions.

Alternatives & Comparisons

Alternative treatments, comparison data, and clinical decision support are pending physician authorship.

Medical Disclaimer

This information is for educational purposes only and does not constitute medical advice, diagnosis, or treatment. Always consult with a qualified healthcare provider regarding any medical condition or treatment plan.

Do not start, stop, or change any treatment without consulting your healthcare provider.

Quick Facts

Type
Substance / Medication
Fully Specified Name
Ondansetron (substance)
SNOMED CT
372487007
UMLS CUI
C0061851
RxNorm CUI
26225
Labeler
A-S Medication Solutions

Clinical Data

This intervention maps to 3 entities in the Ltrl knowledge graph.

3
Conditions
0
Biomarkers
0
Specialists
0
Symptoms
116
Clinical Trials

Data is sourced from SNOMED CT, UMLS, and the Ltrl clinical knowledge graph. Content sections marked as pending require physician authorship. Consult a healthcare provider before starting any treatment.