Substance / Medication

Orphenadrine

SNOMED 372714007 UMLS C0029309

Overview

Active Ingredient

orphenadrine

RxNorm CUI

7715

Indications & Related Conditions

Conditions associated via SNOMED clinical relationships

Myositis

Tetanus

Infection caused by Clostridium tetani

Administration & Protocol

Dosing, route, and treatment protocol

Administration details including route, dosing schedules, preparation instructions, and contraindications are pending physician authorship.

Monitoring & Follow-Up

Biomarkers relevant to this intervention via related conditions

No monitoring biomarkers have been mapped yet. Biomarker-intervention linkages are derived through related conditions and will expand as the knowledge graph grows.

Research Evidence

Published studies and systematic reviews

Sort:

[Pain relief after abdominal oncologic surgery. Evaluation of the effectiveness and safety of a fixed combination of diclofenac and orphenadrine].

Semenkov A V, Skugarev A L, Tulskih D A et al. · Khirurgiia (Mosk) · 2024

PMID: 39268735RCT

Intravenous diclofenac and orphenadrine for the treatment of postoperative pain after remifentanil-based anesthesia : A double-blinded, randomized, placebo-controlled study.

Zeiner Sebastian, Haider Thomas, Zotti Oliver et al. · Wien Klin Wochenschr · 2023

PMID: 36576555RCTFull text (PMC)

[Analgesic and opioid-sparing effects of a fixed combination of diclofenac and orphenadrine in the early postoperative period in cardiac surgery patients].

Eremenko A A, Sorokina L S, Ryabova D V et al. · Zh Nevrol Psikhiatr Im S S Korsakova · 2022

PMID: 36279236RCT

Intravenous ibuprofen versus diclofenac plus orphenadrine in orthognathic surgery: a prospective, randomized, double-blind, controlled clinical study.

Tomic Josip, Wallner Jürgen, Mischak Irene et al. · Clin Oral Investig · 2022

PMID: 35103836RCTFull text (PMC)

A randomized single-dose, two-period crossover bioequivalence study of two fixed-dose Paracetamol/Orphenadrine combination preparations in healthy volunteers under fasted condition.

Cheah Kit Yee, Mah Kar Yee, Pang Lai Hui et al. · BMC Pharmacol Toxicol · 2020

PMID: 32576287RCTFull text (PMC)

Orphenadrine in treatment of muscle cramps in cirrhotic patients: a randomized study.

Abd-Elsalam Sherief, Ebrahim Shaimaa, Soliman Shaimaa et al. · Eur J Gastroenterol Hepatol · 2020

PMID: 31834056RCT

Efficacy and safety of combined piroxicam, dexamethasone, orphenadrine, and cyanocobalamin treatment in mandibular molar surgery.

Barroso A B, Lima V, Guzzo G C et al. · Braz J Med Biol Res · 2006

PMID: 16981050RCT

Development and Validation of Chromatographic Methods for Simultaneous Determination of Paracetamol, Orphenadrine Citrate and Caffeine in Presence of P-aminophenol; Quantification of P-aminophenol Nephrotoxic Impurity Using LC-MS/MS.

Boltia Shereen A, Soudi Aya T, Elzanfaly Eman S et al. · J Chromatogr Sci · 2020

PMID: 31812988Observational

A Randomized, Double-Blind, Placebo-Controlled Trial of Naproxen With or Without Orphenadrine or Methocarbamol for Acute Low Back Pain.

Friedman Benjamin W, Cisewski David, Irizarry Eddie et al. · Ann Emerg Med · 2018

PMID: 29089169ObservationalFull text (PMC)

Intrathecal orphenadrine elicits spinal block in the rat.

Chen Yu-Wen, Tzeng Jann-Inn, Chen Yu-Chung et al. · Eur J Pharmacol · 2014

PMID: 25205132Observational

Research data from MEDLINE/PubMed

Benefits & Expected Outcomes

Benefits, expected outcomes, efficacy data, and NNT (Number Needed to Treat) are pending physician authorship and evidence review.

Risks & Side Effects

Risk profile, common and serious adverse effects, contraindications, and drug interactions are pending physician authorship.

Related Symptoms

Symptoms associated with conditions this intervention addresses

No related symptoms have been mapped yet. Symptom linkages are derived through associated conditions.

Alternatives & Comparisons

Alternative treatments, comparison data, and clinical decision support are pending physician authorship.

Medical Disclaimer

This information is for educational purposes only and does not constitute medical advice, diagnosis, or treatment. Always consult with a qualified healthcare provider regarding any medical condition or treatment plan.

Do not start, stop, or change any treatment without consulting your healthcare provider.

Quick Facts

Type: Substance / Medication
Fully Specified Name: Orphenadrine (substance)
SNOMED CT: 372714007
UMLS CUI: C0029309
RxNorm CUI: 7715

Clinical Data

This intervention maps to 3 entities in the Ltrl knowledge graph.

Conditions

Biomarkers

Specialists

Symptoms

Data is sourced from SNOMED CT, UMLS, and the Ltrl clinical knowledge graph. Content sections marked as pending require physician authorship. Consult a healthcare provider before starting any treatment.