Substance / Medication

Oxcarbazepine

Overview

Active Ingredient
oxcarbazepine
RxNorm CUI
32624

Indications

Oxcarbazepine is indicated for use as monotherapy or adjunctive therapy in the treatment of partial-onset seizures in adults and as monotherapy in the treatment of partial-onset seizures in pediatric patients aged 4 years and above, and as adjunctive therapy in pediatric patients aged 2 years and above with partial-onset seizures.

Labeler: Advagen Pharma LimitedUpdated: 2026-02-24T00:00:00.000ZFull label on DailyMed

Contraindications

When this intervention should not be used

5.2 5.3 see Warnings and Precautions (,) Oxcarbazepine is contraindicated in patients with a known hypersensitivity to oxcarbazepine or to any of its components, or to eslicarbazepine acetate [].

Indications & Related Conditions

Conditions associated via SNOMED clinical relationships

Administration & Protocol

Dosing, route, and treatment protocol

Detailed dosage and administration information is available in the full FDA drug label.

View full prescribing information on DailyMed

Monitoring & Follow-Up

Biomarkers relevant to this intervention via related conditions

No monitoring biomarkers have been mapped yet. Biomarker-intervention linkages are derived through related conditions and will expand as the knowledge graph grows.

Clinical Trials

91 trials linked to this intervention

91
Total Trials
16
Recruiting
33
With Results

Research Evidence

Published studies and systematic reviews

Sort:
Analysis of clinical features of oxcarbazepine-induced Stevens-Johnson syndrome and toxic epidermal necrolysis.
Yan Qingzi, Liu Xiang, Lei Haibo et al. · Front Med (Lausanne) · 2023
PMID: 37881633Meta-AnalysisFull text (PMC)
Adverse fetal and neonatal outcomes following in-utero exposure to oxcarbazepine: A systematic review and meta-analysis.
Athar Farwa, Ehsan Muhammad, Farooq Minaam et al. · Br J Clin Pharmacol · 2022
PMID: 35591806Meta-Analysis
Levetiracetam versus Oxcarbazepine as monotherapy in newly diagnosed focal epilepsy: A systematic review and meta-analysis.
Kharel Sanjeev, Ojha Rajeev, Khanal Surendra · Brain Behav · 2022
PMID: 36184821Meta-AnalysisFull text (PMC)
Oxcarbazepine versus Carbamazepine for the Treatment of Post-Stroke Epilepsy: A Systematic Review and Meta-Analysis.
Zhang Ying-Ju, Lu Xue-Ming, Li Pei-Wu et al. · Turk Neurosurg · 2022
PMID: 34936076Meta-Analysis
Population pharmacokinetics of oxcarbazepine: a systematic review.
Chen Yue-Ting, Wang Chen-Yu, Yin Yi-Wei et al. · Expert Rev Clin Pharmacol · 2021
PMID: 33851561Meta-Analysis
Oxcarbazepine add-on for drug-resistant focal epilepsy.
Bresnahan Rebecca, Atim-Oluk Margaret, Marson Anthony G · Cochrane Database Syst Rev · 2020
PMID: 32129501Meta-AnalysisFull text (PMC)
Association Between HLA genotypes and Oxcarbazepine-induced Cutaneous Adverse Drug Reactions: A Systematic Review and Meta-Analysis.
Tangamornsuksan Wimonchat, Scholfield Norman, Lohitnavy Manupat · J Pharm Pharm Sci · 2018
PMID: 29370880Meta-Analysis
Oxcarbazepine versus phenytoin monotherapy for epilepsy: an individual participant data review.
Nevitt Sarah J, Tudur Smith Catrin, Marson Anthony G · Cochrane Database Syst Rev · 2018
PMID: 30350354Meta-AnalysisFull text (PMC)

Research data from MEDLINE/PubMed

Benefits & Expected Outcomes

Benefits, expected outcomes, efficacy data, and NNT (Number Needed to Treat) are pending physician authorship and evidence review.

Risks & Side Effects

Adverse reaction and safety data for this drug is sourced from the FDA-approved label.

View adverse reactions & drug interactions on DailyMed

Related Symptoms

Symptoms associated with conditions this intervention addresses

No related symptoms have been mapped yet. Symptom linkages are derived through associated conditions.

Alternatives & Comparisons

Alternative treatments, comparison data, and clinical decision support are pending physician authorship.

Medical Disclaimer

This information is for educational purposes only and does not constitute medical advice, diagnosis, or treatment. Always consult with a qualified healthcare provider regarding any medical condition or treatment plan.

Do not start, stop, or change any treatment without consulting your healthcare provider.

Quick Facts

Type
Substance / Medication
Fully Specified Name
Oxcarbazepine (substance)
SNOMED CT
387025007
UMLS CUI
C0069751
RxNorm CUI
32624
Labeler
Advagen Pharma Limited

Clinical Data

This intervention maps to 3 entities in the Ltrl knowledge graph.

3
Conditions
0
Biomarkers
0
Specialists
0
Symptoms
91
Clinical Trials

Data is sourced from SNOMED CT, UMLS, and the Ltrl clinical knowledge graph. Content sections marked as pending require physician authorship. Consult a healthcare provider before starting any treatment.