Substance / Medication

Penicillin G

Overview

Active Ingredient
penicillin G
RxNorm CUI
7980

Indications & Related Conditions

Conditions associated via SNOMED clinical relationships

Administration & Protocol

Dosing, route, and treatment protocol

Administration details including route, dosing schedules, preparation instructions, and contraindications are pending physician authorship.

Monitoring & Follow-Up

Biomarkers relevant to this intervention via related conditions

No monitoring biomarkers have been mapped yet. Biomarker-intervention linkages are derived through related conditions and will expand as the knowledge graph grows.

Clinical Trials

113 trials linked to this intervention

113
Total Trials
30
Recruiting
13
With Results

Research Evidence

Published studies and systematic reviews

Sort:
Severe adverse reactions to benzathine penicillin G in rheumatic heart disease: A systematic review and meta-analysis.
Birru Eshetie Melese, Alene Kefyalew Addis, Manning Laurens et al. · PLoS One · 2025
PMID: 40333929Meta-AnalysisFull text (PMC)
Azithromycin vs penicillin G benzathine for early syphilis: A meta-analysis of randomized controlled trials.
Li Yizhi, Jiang Guan · Dermatol Ther · 2020
PMID: 32677163Meta-Analysis
Factors associated with loss of penicillin G concentrations in serum after intramuscular benzathine penicillin G injection: a meta-analysis.
Broderick Michael P, Hansen Christian J, Faix Dennis J · Pediatr Infect Dis J · 2012
PMID: 22481428Meta-Analysis
Azithromycin versus penicillin G benzathine for early syphilis.
Bai Zheng Gang, Wang Baoxi, Yang Kehu et al. · Cochrane Database Syst Rev · 2012
PMID: 22696367Meta-AnalysisFull text (PMC)
Azithromycin vs. benzathine penicillin G for early syphilis: a meta-analysis of randomized clinical trials.
Bai Zheng-Gang, Yang Ke-Hu, Liu Ya-Li et al. · Int J STD AIDS · 2008
PMID: 18482937Meta-Analysis
Meta-analysis of pharmacokinetic data of veterinary drugs using the Food Animal Residue Avoidance Databank: oxytetracycline and procaine penicillin G.
Craigmill A L, Miller G R, Gehring R et al. · J Vet Pharmacol Ther · 2004
PMID: 15500573Meta-Analysis
Cefixime versus benzathine penicillin G for the treatment of early syphilis-a randomized, controlled open label trial.
Klementová Tamara, Zákoucká Hana, Bížová Beatrice et al. · J Antimicrob Chemother · 2025
PMID: 40795115RCT

Research data from MEDLINE/PubMed

Benefits & Expected Outcomes

Benefits, expected outcomes, efficacy data, and NNT (Number Needed to Treat) are pending physician authorship and evidence review.

Risks & Side Effects

Risk profile, common and serious adverse effects, contraindications, and drug interactions are pending physician authorship.

Related Symptoms

Symptoms associated with conditions this intervention addresses

No related symptoms have been mapped yet. Symptom linkages are derived through associated conditions.

Alternatives & Comparisons

Alternative treatments, comparison data, and clinical decision support are pending physician authorship.

Medical Disclaimer

This information is for educational purposes only and does not constitute medical advice, diagnosis, or treatment. Always consult with a qualified healthcare provider regarding any medical condition or treatment plan.

Do not start, stop, or change any treatment without consulting your healthcare provider.

Quick Facts

Type
Substance / Medication
Fully Specified Name
Benzylpenicillin (substance)
SNOMED CT
323389000
UMLS CUI
C0030827
RxNorm CUI
7980

Clinical Data

This intervention maps to 20 entities in the Ltrl knowledge graph.

20
Conditions
0
Biomarkers
0
Specialists
0
Symptoms
113
Clinical Trials

Data is sourced from SNOMED CT, UMLS, and the Ltrl clinical knowledge graph. Content sections marked as pending require physician authorship. Consult a healthcare provider before starting any treatment.