Substance / Medication

Phentolamine mesylate

Overview

Clinical overview including description, indications, and evidence base is pending physician authorship or FDA SPL integration. Graph-derived relationship data is available below.

Indications & Related Conditions

Conditions associated via SNOMED clinical relationships

Administration & Protocol

Dosing, route, and treatment protocol

Administration details including route, dosing schedules, preparation instructions, and contraindications are pending physician authorship.

Monitoring & Follow-Up

Biomarkers relevant to this intervention via related conditions

No monitoring biomarkers have been mapped yet. Biomarker-intervention linkages are derived through related conditions and will expand as the knowledge graph grows.

Research Evidence

Published studies and systematic reviews

Sort:
Effectiveness of phentolamine mesylate, vibration and photobiomodulation in reducing pain and the reversal of local anesthesia: A systematic review.
Olszewska Aneta, Forszt Dominika, Szymczak Aleksandra et al. · Adv Clin Exp Med · 2025
PMID: 39503279Meta-Analysis
EFFECTIVENESS OF PHENTOLAMINE MESYLATE IN REVERSAL OF LOCAL ANESTHESIA: SYSTEMATIC REVIEW AND META-ANALYSIS.
Sardana Divesh, Lee Johyun, Yiu Cynthia Ky et al. · J Evid Based Dent Pract · 2023
PMID: 37689448Meta-Analysis
Safety profile of phentolamine mesylate as reversal agent of pulpal and soft tissue dental anesthesia: a systematic review and meta-analysis.
Vinnakota Dileep Nag, Kamatham Rekhalakshmi · Quintessence Int · 2019
PMID: 31134227Meta-Analysis
Phentolamine mesylate to reverse oral soft-tissue local anesthesia: A systematic review and meta-analysis.
Prados-Frutos Juan Carlos, Rojo Rosa, González-Serrano José et al. · J Am Dent Assoc · 2015
PMID: 26409985Meta-Analysis
Inferior alveolar nerve block anesthesia in children: The effect of ibuprofen and phentolamine mesylate on pain perception.
Nayak Ullal Anand, Ramasamy Saravanan, Marusamy Kavitha Odathurai et al. · J Indian Soc Pedod Prev Dent · 2024
PMID: 38957911RCT
Phentolamine Mesylate May be a Safe and Effective Option to Reduce Discomfort and Time to Recovery After Dental Care With Local Anesthesia.
Helmi Mohammad, AlDosari Muath, Tavares Mary · J Evid Based Dent Pract · 2018
PMID: 29747805Observational
Effectiveness and safety of phentolamine mesylate in routine dental care.
Daubländer Monika, Liebaug Frank, Niedeggen Gabriele et al. · J Am Dent Assoc · 2017
PMID: 28126226Observational
Local and systemic toxicity of intraoral submucosal injections of phentolamine mesylate (OraVerse).
Rutherford Bruce, Zeller Jillynne R, Thake Daryl · Anesth Prog · 2009
PMID: 20020792ObservationalFull text (PMC)
A randomized phase 2 clinical trial of phentolamine mesylate eye drops in patients with severe night vision disturbances.
Pepose Jay, Brigell Mitchell, Lazar Eliot et al. · BMC Ophthalmol · 2022
PMID: 36209072TrialFull text (PMC)

Research data from MEDLINE/PubMed

Benefits & Expected Outcomes

Benefits, expected outcomes, efficacy data, and NNT (Number Needed to Treat) are pending physician authorship and evidence review.

Risks & Side Effects

Risk profile, common and serious adverse effects, contraindications, and drug interactions are pending physician authorship.

Related Symptoms

Symptoms associated with conditions this intervention addresses

No related symptoms have been mapped yet. Symptom linkages are derived through associated conditions.

Alternatives & Comparisons

Alternative treatments, comparison data, and clinical decision support are pending physician authorship.

Medical Disclaimer

This information is for educational purposes only and does not constitute medical advice, diagnosis, or treatment. Always consult with a qualified healthcare provider regarding any medical condition or treatment plan.

Do not start, stop, or change any treatment without consulting your healthcare provider.

Quick Facts

Type
Substance / Medication
Fully Specified Name
Phentolamine mesilate (substance)
SNOMED CT
32436002
UMLS CUI
C0733398

Clinical Data

This intervention maps to 1 entities in the Ltrl knowledge graph.

1
Conditions
0
Biomarkers
0
Specialists
0
Symptoms

Data is sourced from SNOMED CT, UMLS, and the Ltrl clinical knowledge graph. Content sections marked as pending require physician authorship. Consult a healthcare provider before starting any treatment.