Substance / Medication

Praziquantel

Overview

Active Ingredient
praziquantel
RxNorm CUI
8628

Indications

Praziquantel tablets are indicated in patients aged 1 year and older for the treatment of the following infections: Schistosoma mekongi, Schistosoma japonicum, Schistosoma mansoni and Schistosoma hematobium Schistosomiasis due to all species of schistosoma (for example,), and Clonorchis sinensis/Opisthorchis viverrini Clonorchiasis and Opisthorchiasis due to the liver flukes,(approval of this indication was based on studies in which the two species were not differentiated)

Labeler: Endo USA, Inc.Updated: 2024-02-28T00:00:00.000ZFull label on DailyMed

Contraindications

When this intervention should not be used

Praziquantel is contraindicated in: Patients who previously have shown hypersensitivity to praziquantel or any of the excipients in praziquantel tablets. Patients with ocular cysticercosis; since parasite destruction within the eye that occurs because of hypersensitivity reaction to the dead parasit

Indications & Related Conditions

Conditions associated via SNOMED clinical relationships

Administration & Protocol

Dosing, route, and treatment protocol

Detailed dosage and administration information is available in the full FDA drug label.

View full prescribing information on DailyMed

Monitoring & Follow-Up

Biomarkers relevant to this intervention via related conditions

No monitoring biomarkers have been mapped yet. Biomarker-intervention linkages are derived through related conditions and will expand as the knowledge graph grows.

Clinical Trials

8 trials linked to this intervention

8
Total Trials
2
Recruiting
0
With Results

Research Evidence

Published studies and systematic reviews

Sort:
Evaluating the efficacy of the praziquantel dose pole for schistosomiasis treatment: A multi-country systematic review.
Berry Paprika, Gazzinelli-Guimaraes Pedro H · PLoS Negl Trop Dis · 2025
PMID: 41071847Meta-AnalysisFull text (PMC)
Efficacy of single dose praziquantel against Schistosoma mansoni in East Africa: a systematic review and meta-analysis.
Sisay Miseganaw, Hailu Tadesse, Damtie Destaw et al. · Sci Rep · 2025
PMID: 39920188Meta-AnalysisFull text (PMC)
Praziquantel efficacy, urinary and intestinal schistosomiasis reinfection - a systematic review.
Aboagye Isaac Frimpong, Addison Yvonne Abena Afadua · Pathog Glob Health · 2023
PMID: 36394218Meta-AnalysisFull text (PMC)
In vivo praziquantel efficacy of Schistosoma japonicum over time: A systematic review and meta-analysis.
Yu Qiu-Fu, Zhang Jie-Ying, Sun Meng-Tao et al. · Acta Trop · 2021
PMID: 34273315Meta-Analysis
[Conversion of serum anti-antibodies detected by immunological tests following treatment with praziquantel: a meta-analysis].
Wang L P, Deng W P, Jia T W et al. · Zhongguo Xue Xi Chong Bing Fang Zhi Za Zhi · 2021
PMID: 34008360Meta-Analysis
Efficacy of praziquantel has been maintained over four decades (from 1977 to 2018): A systematic review and meta-analysis of factors influence its efficacy.
Fukushige Mizuho, Chase-Topping Margo, Woolhouse Mark E J et al. · PLoS Negl Trop Dis · 2021
PMID: 33730095Meta-AnalysisFull text (PMC)
High-dose or multi-day praziquantel for imported schistosomiasis? A systematic review.
Cucchetto Giulia, Buonfrate Dora, Marchese Valentina et al. · J Travel Med · 2019
PMID: 31309979Meta-Analysis
Differential impact of mass and targeted praziquantel delivery on schistosomiasis control in school-aged children: A systematic review and meta-analysis.
Cribb Danielle M, Clarke Naomi E, Doi Suhail A R et al. · PLoS Negl Trop Dis · 2019
PMID: 31603895Meta-AnalysisFull text (PMC)
Efficacy of praziquantel treatment regimens in pre-school and school aged children infected with schistosomiasis in sub-Saharan Africa: a systematic review.
Kabuyaya Muhubiri, Chimbari Moses John, Mukaratirwa Samson · Infect Dis Poverty · 2018
PMID: 29986763Meta-AnalysisFull text (PMC)

Research data from MEDLINE/PubMed

Benefits & Expected Outcomes

Benefits, expected outcomes, efficacy data, and NNT (Number Needed to Treat) are pending physician authorship and evidence review.

Risks & Side Effects

Adverse reaction and safety data for this drug is sourced from the FDA-approved label.

View adverse reactions & drug interactions on DailyMed

Related Symptoms

Symptoms associated with conditions this intervention addresses

No related symptoms have been mapped yet. Symptom linkages are derived through associated conditions.

Alternatives & Comparisons

Alternative treatments, comparison data, and clinical decision support are pending physician authorship.

Medical Disclaimer

This information is for educational purposes only and does not constitute medical advice, diagnosis, or treatment. Always consult with a qualified healthcare provider regarding any medical condition or treatment plan.

Do not start, stop, or change any treatment without consulting your healthcare provider.

Quick Facts

Type
Substance / Medication
Fully Specified Name
Praziquantel (substance)
SNOMED CT
387310003
UMLS CUI
C0032911
RxNorm CUI
8628
Labeler
Endo USA, Inc.

Clinical Data

This intervention maps to 8 entities in the Ltrl knowledge graph.

8
Conditions
0
Biomarkers
0
Specialists
0
Symptoms
8
Clinical Trials

Data is sourced from SNOMED CT, UMLS, and the Ltrl clinical knowledge graph. Content sections marked as pending require physician authorship. Consult a healthcare provider before starting any treatment.