Substance / Medication

Prazosin

Overview

Active Ingredient
prazosin
RxNorm CUI
8629

Indications & Related Conditions

Conditions associated via SNOMED clinical relationships

Administration & Protocol

Dosing, route, and treatment protocol

Administration details including route, dosing schedules, preparation instructions, and contraindications are pending physician authorship.

Monitoring & Follow-Up

Biomarkers relevant to this intervention via related conditions

Clinical Trials

7 trials linked to this intervention

7
Total Trials
2
Recruiting
2
With Results

Research Evidence

Published studies and systematic reviews

Sort:
Factors impacting prazosin efficacy for nightmares and insomnia in PTSD patients - a systematic review and meta-regression analysis.
Mendes Thaís Pereira, Pereira Brunno Guimarães, Coutinho Evandro Silva Freire et al. · Prog Neuropsychopharmacol Biol Psychiatry · 2025
PMID: 39828080Meta-Analysis
Prazosin for treatment of post-traumatic stress disorder: a systematic review and meta-analysis.
Reist Christopher, Streja Elani, Tang Cynthia Crystal et al. · CNS Spectr · 2021
PMID: 32362287Meta-Analysis
The effects of prazosin on sleep disturbances in post-traumatic stress disorder: a systematic review and meta-analysis.
Zhang Ye, Ren Rong, Sanford Larry D et al. · Sleep Med · 2020
PMID: 31972510Meta-AnalysisFull text (PMC)
Comparative efficacy of imagery rehearsal therapy and prazosin in the treatment of trauma-related nightmares in adults: A meta-analysis of randomized controlled trials.
Yücel Dilan E, van Emmerik Arnold A P, Souama Camille et al. · Sleep Med Rev · 2020
PMID: 31855732Meta-Analysis
Prazosin in Children and Adolescents With Posttraumatic Stress Disorder Who Have Nightmares: A Systematic Review.
Akinsanya Adefolake, Marwaha Raman, Tampi Rajesh R · J Clin Psychopharmacol · 2017
PMID: 27930498Meta-Analysis
Treatment of Post-Traumatic Stress Disorders with the Alpha-1 Adrenergic Antagonist Prazosin.
Simon Philippe Yves Rémy, Rousseau Pierre-François · Can J Psychiatry · 2017
PMID: 27432823Meta-AnalysisFull text (PMC)
Efficacy of Prazosin in Posttraumatic Stress Disorder: A Systematic Review and Meta-Analysis.
Singh Balwinder, Hughes Andrew J, Mehta Gaurav et al. · Prim Care Companion CNS Disord · 2016
PMID: 27828694Meta-Analysis
Targeting the Noradrenergic System in Posttraumatic Stress Disorder: A Systematic Review and Meta-Analysis of Prazosin Trials.
De Berardis Domenico, Marini Stefano, Serroni Nicola et al. · Curr Drug Targets · 2015
PMID: 25944011Meta-Analysis
Treatment of nightmares with prazosin: a systematic review.
Kung Simon, Espinel Zelde, Lapid Maria I · Mayo Clin Proc · 2012
PMID: 22883741Meta-AnalysisFull text (PMC)
Prazosin for Raynaud's phenomenon in progressive systemic sclerosis.
Pope J, Fenlon D, Thompson A et al. · Cochrane Database Syst Rev · 2000
PMID: 10796398Meta-AnalysisFull text (PMC)

Research data from MEDLINE/PubMed

Benefits & Expected Outcomes

Benefits, expected outcomes, efficacy data, and NNT (Number Needed to Treat) are pending physician authorship and evidence review.

Risks & Side Effects

Risk profile, common and serious adverse effects, contraindications, and drug interactions are pending physician authorship.

Related Symptoms

Symptoms associated with conditions this intervention addresses

No related symptoms have been mapped yet. Symptom linkages are derived through associated conditions.

Alternatives & Comparisons

Alternative treatments, comparison data, and clinical decision support are pending physician authorship.

Medical Disclaimer

This information is for educational purposes only and does not constitute medical advice, diagnosis, or treatment. Always consult with a qualified healthcare provider regarding any medical condition or treatment plan.

Do not start, stop, or change any treatment without consulting your healthcare provider.

Health Goals

Goals connected through associated conditions

Quick Facts

Type
Substance / Medication
Fully Specified Name
Prazosin (substance)
SNOMED CT
387433003
UMLS CUI
C0032912
RxNorm CUI
8629

Clinical Data

This intervention maps to 9 entities in the Ltrl knowledge graph.

5
Conditions
1
Biomarkers
2
Specialists
0
Symptoms
7
Clinical Trials

Data is sourced from SNOMED CT, UMLS, and the Ltrl clinical knowledge graph. Content sections marked as pending require physician authorship. Consult a healthcare provider before starting any treatment.