Overview
Indications
Prochlorperazine Suppositories, USP 25 mg are indicated in the control of severe nausea and vomiting in adults.
Boxed Warning
FDA Black Box Warning
Increased Mortality in Elderly Patients with Dementia-Related Psychosis WARNINGS Elderly patients with dementia-related psychosis treated with antipsychotic drugs are at an increased risk of death. Analyses of seventeen placebo-controlled trials (modal duration of 10 weeks), largely in patients taki
Contraindications
When this intervention should not be used
Do not use in comatose states or in the presence of large amounts of central nervous system depressants (alcohol, barbiturates, narcotics, etc.). Do not use in pediatric surgery. Do not use in children under 2 years of age or under 20 lbs. Do not use in children for conditions for which dosage has n
Indications & Related Conditions
Conditions associated via SNOMED clinical relationships
Administration & Protocol
Dosing, route, and treatment protocol
Detailed dosage and administration information is available in the full FDA drug label.
View full prescribing information on DailyMedMonitoring & Follow-Up
Biomarkers relevant to this intervention via related conditions
Clinical Trials
6 trials linked to this intervention
Recent Trials
Intravenous Fluids in Benign Headaches Trial
Efficacy of Prophylactic Treatment of Oral Prochlorperazine for Acute Mountain Sickness
Designing Optimal Prevention and Management of Postoperative Nausea and Emesis for Patients Undergoing Laparoscopic Sleeve Gastrectomy
Hydromorphone Versus Prochlorperazine + Diphenhydramine for Acute Migraine
Prochlorperazine vs Metoclopramide
Research Evidence
Published studies and systematic reviews
Research data from MEDLINE/PubMed
Benefits & Expected Outcomes
Benefits, expected outcomes, efficacy data, and NNT (Number Needed to Treat) are pending physician authorship and evidence review.
Risks & Side Effects
Adverse reaction and safety data for this drug is sourced from the FDA-approved label.
View adverse reactions & drug interactions on DailyMedRelated Symptoms
Symptoms associated with conditions this intervention addresses
No related symptoms have been mapped yet. Symptom linkages are derived through associated conditions.
Alternatives & Comparisons
Alternative treatments, comparison data, and clinical decision support are pending physician authorship.
This information is for educational purposes only and does not constitute medical advice, diagnosis, or treatment. Always consult with a qualified healthcare provider regarding any medical condition or treatment plan.
Do not start, stop, or change any treatment without consulting your healthcare provider.
Specialists
Providers who commonly manage this intervention
Health Goals
Goals connected through associated conditions
Quick Facts
- Type
- Substance / Medication
- Fully Specified Name
- Prochlorperazine (substance)
- SNOMED CT
- 372853006
- UMLS CUI
- C0033229
- RxNorm CUI
- 8704
- Labeler
- Cosette Pharmaceuticals, Inc.
Clinical Data
This intervention maps to 11 entities in the Ltrl knowledge graph.
Data is sourced from SNOMED CT, UMLS, and the Ltrl clinical knowledge graph. Content sections marked as pending require physician authorship. Consult a healthcare provider before starting any treatment.