Substance / Medication

Progesterone

Overview

Active Ingredient
progesterone
RxNorm CUI
8727

Indications

® ENDOMETRIN(progesterone) is indicated to support embryo implantation and early pregnancy by supplementation of corpus luteal function as part of an Assisted Reproductive Technology (ART) treatment program for infertile women.

Labeler: Ferring Pharmaceuticals Inc.Updated: 2026-02-24T00:00:00.000ZFull label on DailyMed

Contraindications

When this intervention should not be used

ENDOMETRIN is contraindicated in individuals with any of the following conditions: see Description (11) Previous allergic reactions to progesterone or any of the ingredients of ENDOMETRIN [] Undiagnosed vaginal bleeding Known missed abortion or ectopic pregnancy Liver disease Known or suspected mali

Indications & Related Conditions

Conditions associated via SNOMED clinical relationships

Administration & Protocol

Dosing, route, and treatment protocol

Detailed dosage and administration information is available in the full FDA drug label.

View full prescribing information on DailyMed

Monitoring & Follow-Up

Biomarkers relevant to this intervention via related conditions

Clinical Trials

4 trials linked to this intervention

4
Total Trials
1
Recruiting
0
With Results

Research Evidence

Published studies and systematic reviews

Sort:
Progesterone in pregnancy and neonatal outcomes: A systematic review and meta-analysis of randomized controlled trials.
Fernandes Dias Matheus, Do O De Souto Neto Manuel, Alves Duarte Heitor et al. · Int J Gynaecol Obstet · 2026
PMID: 40709632Meta-Analysis
The effect of medroxyprogesterone acetate on apolipoproteins and lipoprotein(a) concentrations in postmenopausal women: A meta-analysis of randomized controlled trials.
Cheng Qiujin, Yan Xiao, Prabahar Kousalya et al. · Prostaglandins Other Lipid Mediat · 2025
PMID: 39542236Meta-Analysis
Association of progesterone receptor status with breast cancer prognosis: a meta-analysis.
Hou Yiming, Li Jianrong, Zhang Qiong et al. · World J Surg Oncol · 2025
PMID: 41035015Meta-AnalysisFull text (PMC)
The effects of progesterone supplementation in pregnancies assessed by doppler ultrasound: a systematic review of maternal and perinatal outcomes.
Khanjani Somayeh, Goodarzi Sheida Bashiri, Khaleghi Mohammad Mehdi et al. · Eur J Med Res · 2025
PMID: 41219813Meta-AnalysisFull text (PMC)
Modulation of sperm function by estrogen and progesterone using in vitro experiments: A systematic review.
Sitali Muloongo C, Chelenga Madalitso · PLoS One · 2025
PMID: 40788945Meta-AnalysisFull text (PMC)
Effect of strategies to increase progesterone levels on fertility of bovine embryo transfer recipients - A meta-analysis.
Alkan Hasan, Tekindal Mustafa Agah, Demirel Mehmet Akif et al. · Theriogenology · 2024
PMID: 38086311Meta-Analysis

Research data from MEDLINE/PubMed

Benefits & Expected Outcomes

Benefits, expected outcomes, efficacy data, and NNT (Number Needed to Treat) are pending physician authorship and evidence review.

Risks & Side Effects

Adverse reaction and safety data for this drug is sourced from the FDA-approved label.

View adverse reactions & drug interactions on DailyMed

Related Symptoms

Symptoms associated with conditions this intervention addresses

No related symptoms have been mapped yet. Symptom linkages are derived through associated conditions.

Alternatives & Comparisons

Alternative treatments, comparison data, and clinical decision support are pending physician authorship.

Medical Disclaimer

This information is for educational purposes only and does not constitute medical advice, diagnosis, or treatment. Always consult with a qualified healthcare provider regarding any medical condition or treatment plan.

Do not start, stop, or change any treatment without consulting your healthcare provider.

Health Goals

Goals connected through associated conditions

Quick Facts

Type
Substance / Medication
Fully Specified Name
Progesterone (substance)
SNOMED CT
16683002
UMLS CUI
C0033308
RxNorm CUI
8727
Labeler
Ferring Pharmaceuticals Inc.

Clinical Data

This intervention maps to 8 entities in the Ltrl knowledge graph.

2
Conditions
3
Biomarkers
2
Specialists
0
Symptoms
4
Clinical Trials

Data is sourced from SNOMED CT, UMLS, and the Ltrl clinical knowledge graph. Content sections marked as pending require physician authorship. Consult a healthcare provider before starting any treatment.