Substance / Medication

Relugolix

Overview

Active Ingredient
relugolix
RxNorm CUI
2472778

Indications

ORGOVYX is indicated for the treatment of adult patients with advanced prostate cancer.

Labeler: Sumitomo Pharma America, Inc.Updated: 2025-10-10T00:00:00.000ZFull label on DailyMed

Contraindications

When this intervention should not be used

ORGOVYX is contraindicated in patients with severe hypersensitivity to relugolix or to any of the product components.

Indications & Related Conditions

Conditions associated via SNOMED clinical relationships

Administration & Protocol

Dosing, route, and treatment protocol

Detailed dosage and administration information is available in the full FDA drug label.

View full prescribing information on DailyMed

Monitoring & Follow-Up

Biomarkers relevant to this intervention via related conditions

Clinical Trials

1 trials linked to this intervention

1
Total Trials
1
Recruiting
0
With Results

Research Evidence

Published studies and systematic reviews

Sort:
Relugolix's impact on endometriosis-associated pain and quality of life: a meta-analysis of EHP-30 outcomes.
Xie Jiani, Ni Xiaorong, Huang Qunhuan et al. · Front Endocrinol (Lausanne) · 2025
PMID: 41089279Meta-AnalysisFull text (PMC)
The Efficacy and Safety of Relugolix Compared with Degarelix in Advanced Prostate Cancer Patients: A Network Meta-analysis of Randomized Trials.
Sari Motlagh Reza, Abufaraj Mohammad, Mori Keiichiro et al. · Eur Urol Oncol · 2022
PMID: 34301529Meta-Analysis
Testosterone Recovery for Relugolix Versus Leuprolide in Men with Advanced Prostate Cancer: Results from the Phase 3 HERO Study.
Tutrone Ronald, Saad Fred, George Daniel J et al. · Eur Urol Oncol · 2024
PMID: 38143206RCT
Relugolix combination therapy in Black/African American women with symptomatic uterine fibroids: LIBERTY Long-Term Extension study.
Stewart Elizabeth A, Al-Hendy Ayman, Lukes Andrea S et al. · Am J Obstet Gynecol · 2024
PMID: 37863160RCT
Impact of relugolix combination therapy on functioning and quality of life in women with endometriosis-associated pain.
As-Sanie Sawsan, Abrao Mauricio S, Reznichenko Galyna et al. · Fertil Steril · 2024
PMID: 38906210RCT
A Randomized Open-Label Study of Relugolix Alone or Relugolix Combination Therapy in Premenopausal Women.
Lukes Andrea, Migoya Elizabeth, Johnson Brendan et al. · Clin Pharmacokinet · 2023
PMID: 37365436RCTFull text (PMC)
Impact of Concomitant Prostate Cancer Medications on Efficacy and Safety of Relugolix Versus Leuprolide in Men With Advanced Prostate Cancer.
George Daniel J, Saad Fred, Cookson Michael S et al. · Clin Genitourin Cancer · 2023
PMID: 37062659RCT
Relugolix combination therapy in European women with symptomatic uterine fibroids: a subgroup analysis from the randomized phase 3 LIBERTY pivotal trials.
Venturella Roberta, Rechberger Tomasz, Zatik János et al. · Gynecol Endocrinol · 2023
PMID: 37634528RCT

Research data from MEDLINE/PubMed

Benefits & Expected Outcomes

Benefits, expected outcomes, efficacy data, and NNT (Number Needed to Treat) are pending physician authorship and evidence review.

Risks & Side Effects

Adverse reaction and safety data for this drug is sourced from the FDA-approved label.

View adverse reactions & drug interactions on DailyMed

Related Symptoms

Symptoms associated with conditions this intervention addresses

No related symptoms have been mapped yet. Symptom linkages are derived through associated conditions.

Alternatives & Comparisons

Alternative treatments, comparison data, and clinical decision support are pending physician authorship.

Medical Disclaimer

This information is for educational purposes only and does not constitute medical advice, diagnosis, or treatment. Always consult with a qualified healthcare provider regarding any medical condition or treatment plan.

Do not start, stop, or change any treatment without consulting your healthcare provider.

Health Goals

Goals connected through associated conditions

Quick Facts

Type
Substance / Medication
Fully Specified Name
Relugolix (substance)
SNOMED CT
1144477009
UMLS CUI
C3896936
RxNorm CUI
2472778
Labeler
Sumitomo Pharma America, Inc.

Clinical Data

This intervention maps to 5 entities in the Ltrl knowledge graph.

1
Conditions
1
Biomarkers
2
Specialists
0
Symptoms
1
Clinical Trials

Data is sourced from SNOMED CT, UMLS, and the Ltrl clinical knowledge graph. Content sections marked as pending require physician authorship. Consult a healthcare provider before starting any treatment.