Substance / Medication

Secnidazole

Overview

Active Ingredient
secnidazole
RxNorm CUI
36314
Labeler: Evofem Inc.Updated: 2025-02-19T00:00:00.000ZFull label on DailyMed

Contraindications

When this intervention should not be used

SOLOSEC is contraindicated: In patients who have shown hypersensitivity to secnidazole, or other nitroimidazole derivatives. Adverse Reactions (6.2) [see] In patients with Cockayne syndrome: Severe irreversible hepatotoxicity/acute liver failure with fatal outcomes have been reported after initiatio

Indications & Related Conditions

Conditions associated via SNOMED clinical relationships

Administration & Protocol

Dosing, route, and treatment protocol

Detailed dosage and administration information is available in the full FDA drug label.

View full prescribing information on DailyMed

Monitoring & Follow-Up

Biomarkers relevant to this intervention via related conditions

No monitoring biomarkers have been mapped yet. Biomarker-intervention linkages are derived through related conditions and will expand as the knowledge graph grows.

Clinical Trials

2 trials linked to this intervention

2
Total Trials
1
Recruiting
0
With Results

Research Evidence

Published studies and systematic reviews

Sort:
Efficacy and safety of single dose of oral secnidazole 2 g in treatment of bacterial vaginosis: A systematic review and meta-analysis.
Elghazaly Shrouk M, Hamam Khaled M, Badawy Marwa M et al. · Eur J Obstet Gynecol Reprod Biol · 2019
PMID: 31129560Meta-Analysis
Secnidazole for treatment of bacterial vaginosis: a systematic review.
Abd El Aziz Mohamed A, Sharifipour Foruzan, Abedi Parvin et al. · BMC Womens Health · 2019
PMID: 31638955Meta-AnalysisFull text (PMC)
Secnidazole Treatment of Bacterial Vaginosis: A Randomized Controlled Trial.
Hillier Sharon L, Nyirjesy Paul, Waldbaum Arthur S et al. · Obstet Gynecol · 2017
PMID: 28697102RCT
Secnidazole and metronidazole in the treatment of Trichomoniasis: Comparative study of the mechanism of action and development of innovative 3D printed intrauterine devices.
Menezes Ágata Giuseppe, Cardoso Fernanda Gomes, Galego Giulia Bongiorni et al. · Microb Pathog · 2026
PMID: 41352518Observational
Biology-oriented drug synthesis and evaluation of secnidazole esters as novel enzyme ınhibitors.
Ansari Muhammad A, Saad Syed M, Khan Khalid M et al. · Arch Pharm (Weinheim) · 2022
PMID: 34862640Observational
An Integrated Efficacy and Safety Analysis of Single-Dose Secnidazole 2 g in the Treatment of Bacterial Vaginosis.
Pentikis Helen, Adetoro Nikki, Tipping Diane et al. · Reprod Sci · 2020
PMID: 32046418ObservationalFull text (PMC)

Research data from MEDLINE/PubMed

Benefits & Expected Outcomes

Benefits, expected outcomes, efficacy data, and NNT (Number Needed to Treat) are pending physician authorship and evidence review.

Risks & Side Effects

Adverse reaction and safety data for this drug is sourced from the FDA-approved label.

View adverse reactions & drug interactions on DailyMed

Related Symptoms

Symptoms associated with conditions this intervention addresses

No related symptoms have been mapped yet. Symptom linkages are derived through associated conditions.

Alternatives & Comparisons

Alternative treatments, comparison data, and clinical decision support are pending physician authorship.

Medical Disclaimer

This information is for educational purposes only and does not constitute medical advice, diagnosis, or treatment. Always consult with a qualified healthcare provider regarding any medical condition or treatment plan.

Do not start, stop, or change any treatment without consulting your healthcare provider.

Quick Facts

Type
Substance / Medication
Fully Specified Name
Secnidazole (substance)
SNOMED CT
713462001
UMLS CUI
C0074246
RxNorm CUI
36314
Labeler
Evofem Inc.

Clinical Data

This intervention maps to 1 entities in the Ltrl knowledge graph.

1
Conditions
0
Biomarkers
0
Specialists
0
Symptoms
2
Clinical Trials

Data is sourced from SNOMED CT, UMLS, and the Ltrl clinical knowledge graph. Content sections marked as pending require physician authorship. Consult a healthcare provider before starting any treatment.