Substance / Medication

Silodosin

Overview

Active Ingredient
silodosin
RxNorm CUI
720825

Indications

Clinical Studies (14) [see] Silodosin, a selective alpha-1 adrenergic receptor antagonist, is indicated for the treatment of the signs and symptoms of benign prostatic hyperplasia (BPH). Silodosin capsules are not indicated for the treatment of hypertension.

Labeler: AvKAREUpdated: 2026-01-15T00:00:00.000ZFull label on DailyMed

Contraindications

When this intervention should not be used

Severe renal impairment (CCr < 30 mL/min) Severe hepatic impairment (Child-Pugh score ≥ 10) Drug Interactions (7.1) [see] Concomitant administration with strong Cytochrome P450 3A4 (CYP3A4) inhibitors (e.g., ketoconazole, clarithromycin, itraconazole, ritonavir) Adverse Reactions (6.2) [see Descript

Indications & Related Conditions

Conditions associated via SNOMED clinical relationships

Administration & Protocol

Dosing, route, and treatment protocol

Detailed dosage and administration information is available in the full FDA drug label.

View full prescribing information on DailyMed

Monitoring & Follow-Up

Biomarkers relevant to this intervention via related conditions

Research Evidence

Published studies and systematic reviews

Sort:
Is silodosin better than tadalafil as a medical expulsive therapy in lower ureter stones?
Abdalaziz Mohab Alsaid Saad, Hanafi Yousif Ahmad, Hamed Belal Mohamed et al. · Arch Ital Urol Androl · 2025
PMID: 40247733Meta-Analysis
Does Silodosin Improve Primary Ureteroscopy Access and Outcomes: Meta-Analysis of Randomized Controlled Trials.
Adhoni Mohammed Zain Ulabedin, Haider Muhammad, Somani Bhaskar et al. · J Endourol · 2024
PMID: 39180290Meta-Analysis
Role of silodosin as medical expulsive therapy in ureteral calculi: a meta-analysis of randomized controlled trials.
Liu Xin-Jian, Wen Jian-Guo, Wan You-Dong et al. · Urolithiasis · 2018
PMID: 28365782Meta-Analysis
Silodosin for the treatment of lower urinary tract symptoms in men with benign prostatic hyperplasia.
Jung Jae Hung, Kim Jiye, MacDonald Roderick et al. · Cochrane Database Syst Rev · 2017
PMID: 29161773Meta-AnalysisFull text (PMC)
The role of Silodosin as a new medical expulsive therapy for ureteral stones: a meta-analysis.
Ding Hui, Ning Zhongyun, Dai Yu et al. · Ren Fail · 2016
PMID: 27687860Meta-Analysis
The efficacy and safety of silodosin for the treatment of ureteral stones: a systematic review and meta-analysis.
Yang Diandong, Wu Jitao, Yuan Hejia et al. · BMC Urol · 2016
PMID: 27233621Meta-AnalysisFull text (PMC)

Research data from MEDLINE/PubMed

Benefits & Expected Outcomes

Benefits, expected outcomes, efficacy data, and NNT (Number Needed to Treat) are pending physician authorship and evidence review.

Risks & Side Effects

Adverse reaction and safety data for this drug is sourced from the FDA-approved label.

View adverse reactions & drug interactions on DailyMed

Related Symptoms

Symptoms associated with conditions this intervention addresses

No related symptoms have been mapped yet. Symptom linkages are derived through associated conditions.

Alternatives & Comparisons

Alternative treatments, comparison data, and clinical decision support are pending physician authorship.

Medical Disclaimer

This information is for educational purposes only and does not constitute medical advice, diagnosis, or treatment. Always consult with a qualified healthcare provider regarding any medical condition or treatment plan.

Do not start, stop, or change any treatment without consulting your healthcare provider.

Health Goals

Goals connected through associated conditions

Quick Facts

Type
Substance / Medication
Fully Specified Name
Silodosin (substance)
SNOMED CT
442042006
UMLS CUI
C1870115
RxNorm CUI
720825
Labeler
AvKARE

Clinical Data

This intervention maps to 6 entities in the Ltrl knowledge graph.

2
Conditions
1
Biomarkers
2
Specialists
0
Symptoms

Data is sourced from SNOMED CT, UMLS, and the Ltrl clinical knowledge graph. Content sections marked as pending require physician authorship. Consult a healthcare provider before starting any treatment.