Substance / Medication

Silybum marianum

Overview

Active Ingredient
milk thistle extract
RxNorm CUI
283579

Indications & Related Conditions

Conditions associated via SNOMED clinical relationships

Administration & Protocol

Dosing, route, and treatment protocol

Administration details including route, dosing schedules, preparation instructions, and contraindications are pending physician authorship.

Monitoring & Follow-Up

Biomarkers relevant to this intervention via related conditions

No monitoring biomarkers have been mapped yet. Biomarker-intervention linkages are derived through related conditions and will expand as the knowledge graph grows.

Clinical Trials

8 trials linked to this intervention

8
Total Trials
1
Recruiting
4
With Results

Research Evidence

Published studies and systematic reviews

Sort:
Are alterations needed in Silybum marianum (Silymarin) administration practices? A novel outlook and meta-analysis on randomized trials targeting liver injury.
Shahsavari Kasra, Ardekani Shireen Shams, Ardekani Mohammad Reza Shams et al. · BMC Complement Med Ther · 2025
PMID: 40221681Meta-AnalysisFull text (PMC)
The Effects of a Fixed Combination of Berberis aristata and Silybum marianum on Dyslipidaemia - A Meta-analysis and Systematic Review.
Tóth Barbara, Németh Dávid, Soós Alexandra et al. · Planta Med · 2020
PMID: 31784970Meta-Analysis
Evaluation of the effect of Silybum marianum extract on menopausal symptoms: A randomized, double-blind placebo-controlled trial.
Saberi Zohreh, Gorji Narjes, Memariani Zahra et al. · Phytother Res · 2020
PMID: 32762030RCT
The role of a fixed Berberis aristata/Silybum marianum combination in the treatment of type 1 diabetes mellitus.
Derosa Giuseppe, D'Angelo Angela, Maffioli Pamela · Clin Nutr · 2016
PMID: 26384091RCT
Berberis aristata combined with Silybum marianum on lipid profile in patients not tolerating statins at high doses.
Derosa Giuseppe, Romano Davide, D'Angelo Angela et al. · Atherosclerosis · 2015
PMID: 25577665RCT

Research data from MEDLINE/PubMed

Benefits & Expected Outcomes

Benefits, expected outcomes, efficacy data, and NNT (Number Needed to Treat) are pending physician authorship and evidence review.

Risks & Side Effects

Risk profile, common and serious adverse effects, contraindications, and drug interactions are pending physician authorship.

Related Symptoms

Symptoms associated with conditions this intervention addresses

No related symptoms have been mapped yet. Symptom linkages are derived through associated conditions.

Alternatives & Comparisons

Alternative treatments, comparison data, and clinical decision support are pending physician authorship.

Medical Disclaimer

This information is for educational purposes only and does not constitute medical advice, diagnosis, or treatment. Always consult with a qualified healthcare provider regarding any medical condition or treatment plan.

Do not start, stop, or change any treatment without consulting your healthcare provider.

Quick Facts

Type
Substance / Medication
Fully Specified Name
Silybum marianum (substance)
SNOMED CT
720488001
UMLS CUI
C0937640
RxNorm CUI
283579

Clinical Data

This intervention maps to 2 entities in the Ltrl knowledge graph.

2
Conditions
0
Biomarkers
0
Specialists
0
Symptoms
8
Clinical Trials

Data is sourced from SNOMED CT, UMLS, and the Ltrl clinical knowledge graph. Content sections marked as pending require physician authorship. Consult a healthcare provider before starting any treatment.