Substance / Medication

Sonidegib

Overview

Active Ingredient
sonidegib
RxNorm CUI
1659191

Indications & Related Conditions

Conditions associated via SNOMED clinical relationships

Administration & Protocol

Dosing, route, and treatment protocol

Administration details including route, dosing schedules, preparation instructions, and contraindications are pending physician authorship.

Monitoring & Follow-Up

Biomarkers relevant to this intervention via related conditions

No monitoring biomarkers have been mapped yet. Biomarker-intervention linkages are derived through related conditions and will expand as the knowledge graph grows.

Research Evidence

Published studies and systematic reviews

Sort:
Safety and Efficacy of Vismodegib and Sonidegib in Advanced Basal Cell Carcinoma of the Head and Neck: A Systematic Review and Meta-Analysis.
Doyle Cindy M, Cevik Jevan, Ramakrishnan Anand · Head Neck · 2026
PMID: 41025405Meta-Analysis
FDA Approval Summary: Sonidegib for Locally Advanced Basal Cell Carcinoma.
Casey Denise, Demko Suzanne, Shord Stacy et al. · Clin Cancer Res · 2017
PMID: 28073840RCT
Multicenter Retrospective Case Series on the Real-World Experience With Sonidegib for the Management of Gorlin Syndrome.
Pérez-Pastor Gemma, Perosanz Lobo Dario, Ciudad Blanco Cristina et al. · Australas J Dermatol · 2025
PMID: 41126702Observational
Disproportionality analysis comparing safety profiles of sonidegib and vismodegib based on the FAERS database.
Zheng Zhixing, Wang Zhengeng, Guo Qinghui et al. · Sci Rep · 2025
PMID: 41174139ObservationalFull text (PMC)
Clinical determinants of clinical response to Sonidegib in advanced basal cell carcinoma: a monocenter experience.
Spallone G, Carbone A, Sperati F et al. · Eur Rev Med Pharmacol Sci · 2024
PMID: 38639529Observational
Sonidegib in the Treatment of Locally Advanced Basal Cell Carcinoma: a Retrospective Study.
Herms Florian, Baroudjian Barouyr, Delyon Julie et al. · Acta Derm Venereol · 2022
PMID: 35604234ObservationalFull text (PMC)

Research data from MEDLINE/PubMed

Benefits & Expected Outcomes

Benefits, expected outcomes, efficacy data, and NNT (Number Needed to Treat) are pending physician authorship and evidence review.

Risks & Side Effects

Risk profile, common and serious adverse effects, contraindications, and drug interactions are pending physician authorship.

Related Symptoms

Symptoms associated with conditions this intervention addresses

No related symptoms have been mapped yet. Symptom linkages are derived through associated conditions.

Alternatives & Comparisons

Alternative treatments, comparison data, and clinical decision support are pending physician authorship.

Medical Disclaimer

This information is for educational purposes only and does not constitute medical advice, diagnosis, or treatment. Always consult with a qualified healthcare provider regarding any medical condition or treatment plan.

Do not start, stop, or change any treatment without consulting your healthcare provider.

Quick Facts

Type
Substance / Medication
Fully Specified Name
Sonidegib (substance)
SNOMED CT
715187001
UMLS CUI
C3886731
RxNorm CUI
1659191

Clinical Data

This intervention maps to 1 entities in the Ltrl knowledge graph.

1
Conditions
0
Biomarkers
0
Specialists
0
Symptoms

Data is sourced from SNOMED CT, UMLS, and the Ltrl clinical knowledge graph. Content sections marked as pending require physician authorship. Consult a healthcare provider before starting any treatment.