Substance / Medication

Tagraxofusp

Overview

Active Ingredient
tagraxofusp
RxNorm CUI
2109055

Indications

ELZONRIS is indicated for the treatment of blastic plasmacytoid dendritic cell neoplasm (BPDCN) in adults and in pediatric patients 2 years and older.

Labeler: Stemline Therapeutics, Inc.Updated: 2024-12-09T00:00:00.000ZFull label on DailyMed

Boxed Warning

FDA Black Box Warning

5.1 [see Warnings and Precautions ()] Capillary Leak Syndrome (CLS) which may be life-threatening or fatal, can occur in patients receiving ELZONRIS. Monitor for signs and symptoms of CLS and take actions as recommended.

Contraindications

When this intervention should not be used

None.

Indications & Related Conditions

Conditions associated via SNOMED clinical relationships

Administration & Protocol

Dosing, route, and treatment protocol

Detailed dosage and administration information is available in the full FDA drug label.

View full prescribing information on DailyMed

Monitoring & Follow-Up

Biomarkers relevant to this intervention via related conditions

No monitoring biomarkers have been mapped yet. Biomarker-intervention linkages are derived through related conditions and will expand as the knowledge graph grows.

Research Evidence

Published studies and systematic reviews

Sort:
Tagraxofusp for Blastic Plasmacytoid Dendritic Cell Neoplasm.
Hammond Danielle, Pemmaraju Naveen · Hematol Oncol Clin North Am · 2020
PMID: 32336420Meta-Analysis
Sustained response to minimal-dose tagraxofusp in a patient with BPDCN and advanced chronic kidney disease.
Brummer Christina, Evert Katja, Keil Felix et al. · Ann Hematol · 2026
PMID: 41535617Case ReportFull text (PMC)
Overcoming Tagraxofusp-Erzs Monotherapy Resistance in Blastic Plasmacytoid Dendritic Cell Neoplasm (BPDCN) in a Real-World Clinical Setting.
Dhakal Prajwal, Sy Mario, Sutamtewagul Grerk et al. · J Immunother Precis Oncol · 2024
PMID: 39219995Case ReportFull text (PMC)
Foot gangrene following Tagraxofusp treatment for blastic plasmacytoid dendritic cell neoplasm: Case report.
Sibai Jad, Chen RuiQi, Nabhani Ibrahim Al et al. · EJHaem · 2022
PMID: 36467820Case ReportFull text (PMC)
Tagraxofusp followed by combined azacitidine and venetoclax in blastic plasmacytoid dendritic cell neoplasm: A case report and literature review.
Samhouri Yazan, Ursu Sorana, Dutton Nina et al. · J Oncol Pharm Pract · 2021
PMID: 32847479Case Report
Blastic Plasmacytoid Dendritic Cell Neoplasm: Underlining the importance of an early diagnosis and the use of tagraxofusp therapy before wide dissemination.
Massone Cesare, Raiola Anna Maria, Dominietto Alida et al. · Australas J Dermatol · 2021
PMID: 32757292Case Report

Research data from MEDLINE/PubMed

Benefits & Expected Outcomes

Benefits, expected outcomes, efficacy data, and NNT (Number Needed to Treat) are pending physician authorship and evidence review.

Risks & Side Effects

Adverse reaction and safety data for this drug is sourced from the FDA-approved label.

View adverse reactions & drug interactions on DailyMed

Related Symptoms

Symptoms associated with conditions this intervention addresses

No related symptoms have been mapped yet. Symptom linkages are derived through associated conditions.

Alternatives & Comparisons

Alternative treatments, comparison data, and clinical decision support are pending physician authorship.

Medical Disclaimer

This information is for educational purposes only and does not constitute medical advice, diagnosis, or treatment. Always consult with a qualified healthcare provider regarding any medical condition or treatment plan.

Do not start, stop, or change any treatment without consulting your healthcare provider.

Quick Facts

Type
Substance / Medication
Fully Specified Name
Tagraxofusp (substance)
SNOMED CT
783435000
UMLS CUI
C4746084
RxNorm CUI
2109055
Labeler
Stemline Therapeutics, Inc.

Clinical Data

This intervention maps to 1 entities in the Ltrl knowledge graph.

1
Conditions
0
Biomarkers
0
Specialists
0
Symptoms

Data is sourced from SNOMED CT, UMLS, and the Ltrl clinical knowledge graph. Content sections marked as pending require physician authorship. Consult a healthcare provider before starting any treatment.