Substance / Medication

Tetrahydrobiopterin

Overview

Active Ingredient
sapropterin
RxNorm CUI
753340

Indications & Related Conditions

Conditions associated via SNOMED clinical relationships

Administration & Protocol

Dosing, route, and treatment protocol

Administration details including route, dosing schedules, preparation instructions, and contraindications are pending physician authorship.

Monitoring & Follow-Up

Biomarkers relevant to this intervention via related conditions

No monitoring biomarkers have been mapped yet. Biomarker-intervention linkages are derived through related conditions and will expand as the knowledge graph grows.

Clinical Trials

10 trials linked to this intervention

10
Total Trials
3
Recruiting
4
With Results

Research Evidence

Published studies and systematic reviews

Sort:
Dietary Liberalization in Tetrahydrobiopterin-Treated PKU Patients: Does It Improve Outcomes?
Evers Roeland A F, van Wegberg Annemiek M J, MacDonald Anita et al. · Nutrients · 2022
PMID: 36145250Meta-AnalysisFull text (PMC)
No effect of acute tetrahydrobiopterin (BH) supplementation on vascular dysfunction in the old.
Bisconti Angela V, Garten Ryan S, Broxterman Ryan M et al. · J Appl Physiol (1985) · 2022
PMID: 35112931RCTFull text (PMC)
Tetrahydrobiopterin improves endothelial function in patients with cystic fibrosis.
Jeong Jin Hee, Lee Nichole, Tucker Matthew A et al. · J Appl Physiol (1985) · 2019
PMID: 30433862RCT
Acute Tetrahydrobiopterin Improves Endothelial Function in Patients With COPD.
Rodriguez-Miguelez Paula, Gregg Justin, Seigler Nichole et al. · Chest · 2018
PMID: 29705218RCT
Tetrahydrobiopterin improves microcirculation in experimental sepsis.
Dumbarton Tristan C, Maxan Alexander, Farah Nizam et al. · Clin Hemorheol Microcirc · 2017
PMID: 28598830RCT
Tetrahydrobiopterin lowers muscle sympathetic nerve activity and improves augmentation index in patients with chronic kidney disease.
Park Jeanie, Liao Peizhou, Sher Salman et al. · Am J Physiol Regul Integr Comp Physiol · 2015
PMID: 25477424RCTFull text (PMC)

Research data from MEDLINE/PubMed

Benefits & Expected Outcomes

Benefits, expected outcomes, efficacy data, and NNT (Number Needed to Treat) are pending physician authorship and evidence review.

Risks & Side Effects

Risk profile, common and serious adverse effects, contraindications, and drug interactions are pending physician authorship.

Related Symptoms

Symptoms associated with conditions this intervention addresses

No related symptoms have been mapped yet. Symptom linkages are derived through associated conditions.

Alternatives & Comparisons

Alternative treatments, comparison data, and clinical decision support are pending physician authorship.

Medical Disclaimer

This information is for educational purposes only and does not constitute medical advice, diagnosis, or treatment. Always consult with a qualified healthcare provider regarding any medical condition or treatment plan.

Do not start, stop, or change any treatment without consulting your healthcare provider.

Quick Facts

Type
Substance / Medication
Fully Specified Name
Tetrahydrobiopterin (substance)
SNOMED CT
259364001
UMLS CUI
C0048897
RxNorm CUI
753340

Clinical Data

This intervention maps to 1 entities in the Ltrl knowledge graph.

1
Conditions
0
Biomarkers
0
Specialists
0
Symptoms
10
Clinical Trials

Data is sourced from SNOMED CT, UMLS, and the Ltrl clinical knowledge graph. Content sections marked as pending require physician authorship. Consult a healthcare provider before starting any treatment.