Substance / Medication

Trientine tetrahydrochloride

Overview

Clinical overview including description, indications, and evidence base is pending physician authorship or FDA SPL integration. Graph-derived relationship data is available below.

Indications & Related Conditions

Conditions associated via SNOMED clinical relationships

Administration & Protocol

Dosing, route, and treatment protocol

Administration details including route, dosing schedules, preparation instructions, and contraindications are pending physician authorship.

Monitoring & Follow-Up

Biomarkers relevant to this intervention via related conditions

No monitoring biomarkers have been mapped yet. Biomarker-intervention linkages are derived through related conditions and will expand as the knowledge graph grows.

Research Evidence

Published studies and systematic reviews

Sort:
Trientine Tetrahydrochloride, From Bench to Bedside: A Narrative Review.
Kamlin C Omar F, M Jenkins Timothy, L Heise Jamie et al. · Drugs · 2024
PMID: 39420162ReviewFull text (PMC)
Authors' Reply to Purchase's Comment on "Trientine Tetrahydrochloride, from Bench to Beside: A Narrative Review".
Kamlin C Omar F, Jenkins Timothy M, Heise Jamie L et al. · Drugs · 2025
PMID: 39804421Other
Clinical experience on switching trientine tetrahydrochloride to trientine dihydrochloride in Wilson disease patients.
Mohr Isabelle, Schmitt Timo, Weber Christophe et al. · JIMD Rep · 2024
PMID: 39512437OtherFull text (PMC)
Trientine tetrahydrochloride versus penicillamine for maintenance therapy in Wilson disease (CHELATE): a randomised, open-label, non-inferiority, phase 3 trial.
Schilsky Michael L, Czlonkowska Anna, Zuin Massimo et al. · Lancet Gastroenterol Hepatol · 2022
PMID: 36183738Trial
Comparison of the Pharmacokinetic Profiles of Trientine Tetrahydrochloride and Trientine Dihydrochloride in Healthy Subjects.
Weiss Karl Heinz, Thompson Catherine, Dogterom Peter et al. · Eur J Drug Metab Pharmacokinet · 2021
PMID: 34357516Trial

Research data from MEDLINE/PubMed

Benefits & Expected Outcomes

Benefits, expected outcomes, efficacy data, and NNT (Number Needed to Treat) are pending physician authorship and evidence review.

Risks & Side Effects

Risk profile, common and serious adverse effects, contraindications, and drug interactions are pending physician authorship.

Related Symptoms

Symptoms associated with conditions this intervention addresses

No related symptoms have been mapped yet. Symptom linkages are derived through associated conditions.

Alternatives & Comparisons

Alternative treatments, comparison data, and clinical decision support are pending physician authorship.

Medical Disclaimer

This information is for educational purposes only and does not constitute medical advice, diagnosis, or treatment. Always consult with a qualified healthcare provider regarding any medical condition or treatment plan.

Do not start, stop, or change any treatment without consulting your healthcare provider.

Quick Facts

Type
Substance / Medication
Fully Specified Name
Trientine tetrahydrochloride (substance)
SNOMED CT
1149496005
UMLS CUI
C5207636

Clinical Data

This intervention maps to 2 entities in the Ltrl knowledge graph.

2
Conditions
0
Biomarkers
0
Specialists
0
Symptoms

Data is sourced from SNOMED CT, UMLS, and the Ltrl clinical knowledge graph. Content sections marked as pending require physician authorship. Consult a healthcare provider before starting any treatment.