Substance / Medication

Trimethoprim

Overview

Active Ingredient
trimethoprim
RxNorm CUI
10829

Indications

To reduce the development of drug-resistant bacteria and maintain the effectiveness of sulfamethoxazole and trimethoprim oral suspension and other antibacterial drugs, sulfamethoxazole and trimethoprim oral suspension should be used only to treat or prevent infections that are proven or strongly suspected to be caused by susceptible bacteria. When culture and susceptibility information are available, they should be considered in selecting or modifying antibacterial therapy. In the absence of suc

Labeler: Chartwell Governmental & Specialty RX, LLC.Updated: 2026-02-24T00:00:00.000ZFull label on DailyMed

Contraindications

When this intervention should not be used

Sulfamethoxazole and trimethoprim is contraindicated in the following situations: known hypersensitivity to trimethoprim or sulfonamides history of drug-induced immune thrombocytopenia with use of trimethoprim and/or sulfonamides documented megaloblastic anemia due to folate deficiency pediatric pat

Indications & Related Conditions

Conditions associated via SNOMED clinical relationships

Administration & Protocol

Dosing, route, and treatment protocol

Detailed dosage and administration information is available in the full FDA drug label.

View full prescribing information on DailyMed

Monitoring & Follow-Up

Biomarkers relevant to this intervention via related conditions

No monitoring biomarkers have been mapped yet. Biomarker-intervention linkages are derived through related conditions and will expand as the knowledge graph grows.

Clinical Trials

8 trials linked to this intervention

8
Total Trials
5
Recruiting
2
With Results

Research Evidence

Published studies and systematic reviews

Sort:
Low-dose trimethoprim-sulfamethoxazole for prophylaxis ofpneumonia in HIV-uninfected patients: a systematic review and meta-analysis.
Huang Hui-Bin, Shi Jia-Heng, Hu Yan-Ge et al. · Front Pharmacol · 2025
PMID: 40735480Meta-AnalysisFull text (PMC)
Acute aseptic meningitis temporally associated with trimethoprim and sulfamethoxazole: Systematic review.
Bernasconi Gianmaria F, Milani Gregorio P, De Felice Elisabetta L T et al. · Br J Clin Pharmacol · 2025
PMID: 39540422Meta-Analysis
Clinical features, risk factors, diagnosis, and treatment of trimethoprim-sulfamethoxazole-induced hypoglycemia.
Wang Chunjiang, Fang Weijin, Li Zuojun et al. · Front Endocrinol (Lausanne) · 2023
PMID: 36843590Meta-AnalysisFull text (PMC)
Meta-analysis of echinocandins combined with trimethoprim-sulfamethoxazole for treatment of Pneumocystis pneumonia.
Guo Jiayu, Chen Zhongbao, Kong Chenyang et al. · J Chemother · 2023
PMID: 35815561Meta-Analysis
Trimethoprim-Sulfamethoxazole (Bactrim) Dose Optimization inPneumonia (PCP) Management: A Systematic Review.
Haseeb Abdul, Abourehab Mohammed A S, Almalki Wesam Abdulghani et al. · Int J Environ Res Public Health · 2022
PMID: 35270525Meta-AnalysisFull text (PMC)

Research data from MEDLINE/PubMed

Benefits & Expected Outcomes

Benefits, expected outcomes, efficacy data, and NNT (Number Needed to Treat) are pending physician authorship and evidence review.

Risks & Side Effects

Adverse reaction and safety data for this drug is sourced from the FDA-approved label.

View adverse reactions & drug interactions on DailyMed

Related Symptoms

Symptoms associated with conditions this intervention addresses

No related symptoms have been mapped yet. Symptom linkages are derived through associated conditions.

Alternatives & Comparisons

Alternative treatments, comparison data, and clinical decision support are pending physician authorship.

Medical Disclaimer

This information is for educational purposes only and does not constitute medical advice, diagnosis, or treatment. Always consult with a qualified healthcare provider regarding any medical condition or treatment plan.

Do not start, stop, or change any treatment without consulting your healthcare provider.

Quick Facts

Type
Substance / Medication
Fully Specified Name
Trimethoprim (substance)
SNOMED CT
387179001
UMLS CUI
C0041041
RxNorm CUI
10829
Labeler
Chartwell Governmental & Specialty RX, LLC.

Clinical Data

This intervention maps to 10 entities in the Ltrl knowledge graph.

10
Conditions
0
Biomarkers
0
Specialists
0
Symptoms
8
Clinical Trials

Data is sourced from SNOMED CT, UMLS, and the Ltrl clinical knowledge graph. Content sections marked as pending require physician authorship. Consult a healthcare provider before starting any treatment.