Substance / Medication

Trimethylpsoralen

Overview

Active Ingredient
trioxsalen
RxNorm CUI
10844

Indications & Related Conditions

Conditions associated via SNOMED clinical relationships

Administration & Protocol

Dosing, route, and treatment protocol

Administration details including route, dosing schedules, preparation instructions, and contraindications are pending physician authorship.

Monitoring & Follow-Up

Biomarkers relevant to this intervention via related conditions

No monitoring biomarkers have been mapped yet. Biomarker-intervention linkages are derived through related conditions and will expand as the knowledge graph grows.

Clinical Trials

159 trials linked to this intervention

159
Total Trials
31
Recruiting
61
With Results

Research Evidence

Published studies and systematic reviews

Sort:
An intraindividual comparative study of psoralen-UVA erythema induced by bath 8-methoxypsoralen and 4, 5', 8-trimethylpsoralen.
Man Irene, McKinlay Jayne, Dawe Robert S et al. · J Am Acad Dermatol · 2003
PMID: 12833009Observational
Time course of skin photosensitivity following trimethylpsoralen bath PUVA.
Man I, Wainwright N J, Gibbs N K et al. · Photodermatol Photoimmunol Photomed · 2000
PMID: 11068860Observational
Synthesis of Oligonucleotides Containing 4,5',8-Trimethylpsoralen at the 2'-O Position and Their Cross-Linking Properties with RNAs.
Kobori Akio, Yamayoshi Asako, Murakami Akira · Curr Protoc Nucleic Acid Chem · 2014
PMID: 25199638Review
Selective cross-linking behavior of oligodeoxyribonucleotides containing 2'--[-(4,5',8-trimethylpsoralen-4'-ylmethylcarbamoyl)]adenosine to mutantDNA.
Yamayoshi Asako, Higuchi Maiko, Sakai Yui et al. · Nucleosides Nucleotides Nucleic Acids · 2020
PMID: 31645189Other
Spectral study of interactions of 4,8,4'-trimethylpsoralen and 4,4'-dimethylangelicin dyes with DNA.
Sibirtsev V S, Tolmachev A Yu, Kovaleva M V et al. · Biochemistry (Mosc) · 2005
PMID: 16097948Other
Methods for single/low-copy integration by ultraviolet and trimethylpsoralen treatment in Caenorhabditis elegans.
Kage-Nakadai Eriko, Imae Rieko, Yoshina Sawako et al. · Methods · 2014
PMID: 24613935Preclinical
Single/low-copy integration of transgenes in Caenorhabditis elegans using an ultraviolet trimethylpsoralen method.
Kage-Nakadai Eriko, Kobuna Hiroyuki, Funatsu Osamu et al. · BMC Biotechnol · 2012
PMID: 22217006PreclinicalFull text (PMC)
Randomized half-side comparison of narrowband UVB and trimethylpsoralen bath plus UVA treatments for psoriasis.
Snellman Erna, Klimenko Taras, Rantanen Tapio · Acta Derm Venereol · 2004
PMID: 15206693Trial
Characterization of trimethylpsoralen as a mutagen for mouse embryonic stem cells.
Greber Boris, Lehrach Hans, Himmelbauer Heinz · Mutat Res · 2003
PMID: 12650906Preclinical

Research data from MEDLINE/PubMed

Benefits & Expected Outcomes

Benefits, expected outcomes, efficacy data, and NNT (Number Needed to Treat) are pending physician authorship and evidence review.

Risks & Side Effects

Risk profile, common and serious adverse effects, contraindications, and drug interactions are pending physician authorship.

Related Symptoms

Symptoms associated with conditions this intervention addresses

No related symptoms have been mapped yet. Symptom linkages are derived through associated conditions.

Alternatives & Comparisons

Alternative treatments, comparison data, and clinical decision support are pending physician authorship.

Medical Disclaimer

This information is for educational purposes only and does not constitute medical advice, diagnosis, or treatment. Always consult with a qualified healthcare provider regarding any medical condition or treatment plan.

Do not start, stop, or change any treatment without consulting your healthcare provider.

Quick Facts

Type
Substance / Medication
Fully Specified Name
Trioxsalen (substance)
SNOMED CT
35464001
UMLS CUI
C0041086
RxNorm CUI
10844

Clinical Data

This intervention maps to 3 entities in the Ltrl knowledge graph.

3
Conditions
0
Biomarkers
0
Specialists
0
Symptoms
159
Clinical Trials

Data is sourced from SNOMED CT, UMLS, and the Ltrl clinical knowledge graph. Content sections marked as pending require physician authorship. Consult a healthcare provider before starting any treatment.