Substance / Medication

Ubrogepant

Overview

Active Ingredient
ubrogepant
RxNorm CUI
2268216

Indications

UBRELVY is indicated for the acute treatment of migraine with or without aura in adults. Limitations of Use UBRELVY is not indicated for the preventive treatment of migraine.

Labeler: Allergan, Inc.Updated: 2025-06-05T00:00:00.000ZFull label on DailyMed

Contraindications

When this intervention should not be used

UBRELVY is contraindicated: [see Drug Interactions ( 7.1 )] With concomitant use of strong CYP3A4 inhibitors [see Warnings and Precautions ( 5.1 )] In patients with a history of serious hypersensitivity to ubrogepant or any component of UBRELVY. Reactions have included anaphylaxis, dyspnea, and faci

Indications & Related Conditions

Conditions associated via SNOMED clinical relationships

Administration & Protocol

Dosing, route, and treatment protocol

Detailed dosage and administration information is available in the full FDA drug label.

View full prescribing information on DailyMed

Monitoring & Follow-Up

Biomarkers relevant to this intervention via related conditions

No monitoring biomarkers have been mapped yet. Biomarker-intervention linkages are derived through related conditions and will expand as the knowledge graph grows.

Clinical Trials

2 trials linked to this intervention

2
Total Trials
1
Recruiting
1
With Results

Research Evidence

Published studies and systematic reviews

Sort:
Efficacy of ubrogepant and atogepant in males and females with migraine: A secondary analysis of randomized clinical trials.
Goadsby Peter J, Jürgens Tim P, Brand-Schieber Elimor et al. · Cephalalgia · 2025
PMID: 39982105Meta-Analysis
Efficacy and safety of ubrogepant for migraine: a meta-analysis of randomized controlled studies.
Wu Shu-Zhi, Chen Linglong · Int J Neurosci · 2024
PMID: 35999672Meta-Analysis
Efficacy of lasmiditan, rimegepant and ubrogepant for acute treatment of migraine in triptan insufficient responders: systematic review and network meta-analysis.
Laohapiboolrattana Wattakorn, Jansem Priabprat, Anukoolwittaya Prakit et al. · J Headache Pain · 2024
PMID: 39516789Meta-AnalysisFull text (PMC)
Ubrogepant and rimegepant: systematic review, meta-analysis, and meta-regression of clinical studies.
Dong Guojun, Kjærgaard Naoko Adachi, Shakibfar Saeed et al. · Expert Opin Drug Saf · 2023
PMID: 36737057Meta-Analysis
Relative efficacy of lasmiditan versus rimegepant and ubrogepant as acute treatments for migraine: network meta-analysis findings.
Polavieja Pepa, Belger Mark, Venkata Shiva Kumar et al. · J Headache Pain · 2022
PMID: 35790906Meta-AnalysisFull text (PMC)
Comparative efficacy and safety of rimegepant, ubrogepant, and lasmiditan for acute treatment of migraine: a network meta-analysis.
Johnston Karissa, Popoff Evan, Deighton Alison et al. · Expert Rev Pharmacoecon Outcomes Res · 2022
PMID: 34148501Meta-Analysis
Calcitonin gene-related peptide receptor antagonist ubrogepant for the treatment of acute migraine: A meta-analysis.
Zhang Zizhen, Shu Yunfeng, Diao Yun et al. · Medicine (Baltimore) · 2021
PMID: 33663087Meta-AnalysisFull text (PMC)
Safety and Efficacy of Ubrogepant for the Acute Treatment of Episodic Migraine: A Meta-Analysis of Randomized Clinical Trials.
Yang Yanbo, Chen Mingjia, Sun Yue et al. · CNS Drugs · 2020
PMID: 32193827Meta-Analysis

Research data from MEDLINE/PubMed

Benefits & Expected Outcomes

Benefits, expected outcomes, efficacy data, and NNT (Number Needed to Treat) are pending physician authorship and evidence review.

Risks & Side Effects

Adverse reaction and safety data for this drug is sourced from the FDA-approved label.

View adverse reactions & drug interactions on DailyMed

Related Symptoms

Symptoms associated with conditions this intervention addresses

No related symptoms have been mapped yet. Symptom linkages are derived through associated conditions.

Alternatives & Comparisons

Alternative treatments, comparison data, and clinical decision support are pending physician authorship.

Medical Disclaimer

This information is for educational purposes only and does not constitute medical advice, diagnosis, or treatment. Always consult with a qualified healthcare provider regarding any medical condition or treatment plan.

Do not start, stop, or change any treatment without consulting your healthcare provider.

Quick Facts

Type
Substance / Medication
Fully Specified Name
Ubrogepant (substance)
SNOMED CT
838467004
UMLS CUI
C4505936
RxNorm CUI
2268216
Labeler
Allergan, Inc.

Clinical Data

This intervention maps to 2 entities in the Ltrl knowledge graph.

2
Conditions
0
Biomarkers
0
Specialists
0
Symptoms
2
Clinical Trials

Data is sourced from SNOMED CT, UMLS, and the Ltrl clinical knowledge graph. Content sections marked as pending require physician authorship. Consult a healthcare provider before starting any treatment.