Treatments & Interventions
Signs & Symptoms
Based on Human Phenotype Ontology (HPO) disease-phenotype annotations.
Amyotrophic lateral sclerosis
Always present (100%)HP:0007354
Motor neuron atrophy
Very frequent (80-99%)HP:0007373
Muscle weakness, generalised
Very frequent (80-99%)HP:0003324
Neurodegeneration
Very frequent (80-99%)HP:0002180
Abnormal spirometry test
Frequent (30-79%)HP:0030878
Behavioral changes
Frequent (30-79%)HP:0000708
Deglutition disorder
Frequent (30-79%)HP:0002015
Depressive episode
Frequent (30-79%)HP:0000716
Difficulty articulating speech
Frequent (30-79%)HP:0001260
Difficulty breathing
Frequent (30-79%)HP:0002094
Distal muscle atrophy, upper and lower limbs
Frequent (30-79%)HP:0003693
Dysphonia
Frequent (30-79%)HP:0001618
Emotional lability
Frequent (30-79%)HP:0000712
Excessive, persistent worry and fear
Frequent (30-79%)HP:0000739
Extensor plantar responses
Frequent (30-79%)HP:0003487
Fatigable weakness of bulbar muscles
Frequent (30-79%)HP:0030192
Fatigable weakness of respiratory muscles
Frequent (30-79%)HP:0030196
Fatigable weakness of swallowing muscles
Frequent (30-79%)HP:0030195
Hoffmann's sign
Frequent (30-79%)HP:0031993
Increased reflexes
Frequent (30-79%)HP:0001347
Intellectual impairment
Frequent (30-79%)HP:0100543
Involuntary muscle stiffness, contraction, or spasm
Frequent (30-79%)HP:0001257
Lower limb muscle weakness
Frequent (30-79%)HP:0007340
Muscle fasciculation
Frequent (30-79%)HP:0002380
Muscle spasm
Frequent (30-79%)HP:0003394
Muscle wasting
Frequent (30-79%)HP:0003202
Pain
Frequent (30-79%)HP:0012531
Paralysis
Frequent (30-79%)HP:0003470
Progressive distal muscular atrophy
Frequent (30-79%)HP:0008955
Respiratory failure
Frequent (30-79%)HP:0002878
Related Conditions
Amyotrophic lateral sclerosis with dementia(child)
Juvenile amyotrophic lateral sclerosis(child)
Amyotrophic lateral sclerosis plus syndrome(child)
Amyotrophic lateral sclerosis type 4(child)
Amyotrophic lateral sclerosis, parkinsonism, dementia of Guam syndrome(child)
Amyotrophic lateral sclerosis type 1(child)
Amyotrophic lateral sclerosis type 3(child)
Amyotrophic lateral sclerosis type 6(child)
Amyotrophic lateral sclerosis type 7(child)
ALS8 - amyotrophic lateral sclerosis type 8(child)
ALS9 - amyotrophic lateral sclerosis type 9(child)
ALS10 - amyotrophic lateral sclerosis type 10(child)
Amyotrophic lateral sclerosis with parkinsonism(child)
Motor neuron disease(parent)
Quick Facts
- SNOMED CT
- 86044005
- UMLS CUI
- C0002736
- Fully Specified Name
- Amyotrophic lateral sclerosis (disorder)
- Specialists
- 0
- Diagnostic Biomarkers
- 0
- HPO Phenotypes
- 30
- Known Treatments
- 3
Medical Disclaimer
This information is for educational purposes only and does not constitute medical advice, diagnosis, or treatment. Always consult with a qualified healthcare provider regarding any medical condition or treatment plan.
Clinical content is derived from the SNOMED CT clinical ontology and curated medical knowledge graphs.