Overview
Amyotrophic lateral sclerosis type 4 is a disorder.
Auto-generated from clinical reference data. Not a substitute for medical advice.
Signs & Symptoms
Based on Human Phenotype Ontology (HPO) disease-phenotype annotations.
Degeneration of alpha-motor neurons in anterior horn cells of the spinal cord
Always present (100%)HP:0002398
Degeneration of the spinal cord
Always present (100%)HP:0006827
Corticospinal signs
Frequent (30-79%)HP:0007256
Distal limb muscle weakness due to peripheral neuropathy
Frequent (30-79%)HP:0002460
Extensor plantar responses
Frequent (30-79%)HP:0003487
Muscle atrophy, neurogenic
Frequent (30-79%)HP:0003202
Clonus
Occasional (5-29%)HP:0002169
Gait disturbance
Occasional (5-29%)HP:0001288
Pes cavus
Occasional (5-29%)HP:0001761
Sensory impairment
Occasional (5-29%)HP:0003474
Spastic paraplegia
Occasional (5-29%)HP:0001258
Amyotrophic lateral sclerosis
HP:0007354
Axonal degeneration
HP:0040078
Decreased CMAP amplitude
HP:0033383
Diffuse axonal swelling
HP:0003405
Distal muscle atrophy, upper and lower limbs
HP:0003693
EMG: positive sharp waves
HP:0030007
Increased reflexes
HP:0001347
Lower motor neuron manifestations
HP:0002366
Muscle fibrillation
HP:0010546
Pallor of dorsal columns of the spinal cord
HP:0006825
Peripheral axonal degeneration
HP:0000764
Quick Facts
- SNOMED CT
- 784341001
- UMLS CUI
- C1865409
- Fully Specified Name
- Amyotrophic lateral sclerosis type 4 (disorder)
- Specialists
- 0
- Diagnostic Biomarkers
- 0
- HPO Phenotypes
- 22
Medical Disclaimer
This information is for educational purposes only and does not constitute medical advice, diagnosis, or treatment. Always consult with a qualified healthcare provider regarding any medical condition or treatment plan.
Clinical content is derived from the SNOMED CT clinical ontology and curated medical knowledge graphs.