Autosomal dominant spastic paraplegia type 10

disorder

SNOMED 732948003CUI C1858712

Overview

Autosomal dominant spastic paraplegia type 10 is a disorder.

Auto-generated from clinical reference data. Not a substitute for medical advice.

Signs & Symptoms

Based on Human Phenotype Ontology (HPO) disease-phenotype annotations.

Lower limb hypertonia

Always present (100%)HP:0006895

Spastic walk

Always present (100%)HP:0002064

Spasticity of lower limb

Always present (100%)HP:0002061

Lower limb degeneration

Very frequent (80-99%)HP:0008944

Lower limb hyperreflexia

Very frequent (80-99%)HP:0002395

Axonal neuropathy

Frequent (30-79%)HP:0003477

Decreased distal vibration sense

Frequent (30-79%)HP:0006886

Distal sensory loss, especially vibratory sense

Frequent (30-79%)HP:0002166

Extensor plantar responses

Frequent (30-79%)HP:0003487

Leg muscle stiffness

Frequent (30-79%)HP:0008969

Loss of distal sensation

Frequent (30-79%)HP:0002936

Lower limb muscle weakness

Frequent (30-79%)HP:0007340

Pyramidal tract dysfunction

Frequent (30-79%)HP:0002493

Rod-cone dystrophy

Frequent (30-79%)HP:0000510

Spastic paraparetic gait

Frequent (30-79%)HP:0031958

Spastic/hyperactive bladder

Frequent (30-79%)HP:0005340

Upper limb hyperreflexia

Frequent (30-79%)HP:0007350

Upper limb muscle weakness

Frequent (30-79%)HP:0003484

Urinary urgency

Frequent (30-79%)HP:0000012

Amyotrophy involving the upper limbs

Occasional (5-29%)HP:0009129

Ataxia

Occasional (5-29%)HP:0001251

Dupuytren contracture

Occasional (5-29%)HP:0005679

Moderate mental retardation

Occasional (5-29%)HP:0002342

Nerve damage causing decreased feeling and movement

Occasional (5-29%)HP:0007141

Paresthesia

Occasional (5-29%)HP:0003401

Parkinsonian disease

Occasional (5-29%)HP:0001300

Pes cavus

Occasional (5-29%)HP:0001761

Varicose veins

Occasional (5-29%)HP:0002619

Ankle clonus

Very rare (1-4%)HP:0011448

Cognitive deficits

Very rare (1-4%)HP:0100543

Related Conditions

Autosomal dominant hereditary spastic paraplegia(parent)

Quick Facts

SNOMED CT: 732948003
UMLS CUI: C1858712
Fully Specified Name: Autosomal dominant spastic paraplegia type 10 (disorder)
Specialists: 0
Diagnostic Biomarkers: 0
HPO Phenotypes: 30

Medical Disclaimer

This information is for educational purposes only and does not constitute medical advice, diagnosis, or treatment. Always consult with a qualified healthcare provider regarding any medical condition or treatment plan.

Clinical content is derived from the SNOMED CT clinical ontology and curated medical knowledge graphs.