Autosomal dominant spastic paraplegia type 3

disorder

SNOMED 782670003CUI C2931355

Overview

Autosomal dominant spastic paraplegia type 3 is a disorder.

Auto-generated from clinical reference data. Not a substitute for medical advice.

Signs & Symptoms

Based on Human Phenotype Ontology (HPO) disease-phenotype annotations.

Lower limb muscle weakness

Always present (100%)HP:0007340

Distal muscle weakness in lower limbs

Very frequent (80-99%)HP:0009053

Extensor plantar responses

Very frequent (80-99%)HP:0003487

Lower limb hyperreflexia

Very frequent (80-99%)HP:0002395

Spasticity of lower limb

Very frequent (80-99%)HP:0002061

Ankle clonus

Frequent (30-79%)HP:0011448

Gait disturbance

Frequent (30-79%)HP:0001288

Lower limb degeneration

Frequent (30-79%)HP:0008944

Spastic walk

Frequent (30-79%)HP:0002064

Delayed motor milestones

Occasional (5-29%)HP:0001270

Hypoplasia of corpus callosum

Occasional (5-29%)HP:0002079

Impaired vibratory sensation

Occasional (5-29%)HP:0002495

Mental retardation, mild

Occasional (5-29%)HP:0001256

Neuropathy

Occasional (5-29%)HP:0009830

Urgency frequency syndrome

Occasional (5-29%)HP:0000012

Walking on tiptoes

Occasional (5-29%)HP:0030051

Difficulty articulating speech

Very rare (1-4%)HP:0001260

Frequent falls

Very rare (1-4%)HP:0002359

Hyperesthesia

Very rare (1-4%)HP:0100963

Lower limb hypertonia

Very rare (1-4%)HP:0006895

Muscle rigidity

Very rare (1-4%)HP:0002063

Slowness of movements

Very rare (1-4%)HP:0002067

Very poor growth

Very rare (1-4%)HP:0001510

Cavus foot

HP:0001761

Cobb angle greater than ten degrees

HP:0002650

Degeneration of the lateral corticospinal tracts

HP:0002314

Distal sensory loss, especially vibratory sense

HP:0002166

Increased reflexes

HP:0001347

Leg paralysis

HP:0010550

Spastic paraplegia

HP:0001258

Related Conditions

Autosomal dominant hereditary spastic paraplegia(parent)

Quick Facts

SNOMED CT: 782670003
UMLS CUI: C2931355
Fully Specified Name: Autosomal dominant spastic paraplegia type 3 (disorder)
Specialists: 0
Diagnostic Biomarkers: 0
HPO Phenotypes: 30

Medical Disclaimer

This information is for educational purposes only and does not constitute medical advice, diagnosis, or treatment. Always consult with a qualified healthcare provider regarding any medical condition or treatment plan.

Clinical content is derived from the SNOMED CT clinical ontology and curated medical knowledge graphs.