Paroxysmal nocturnal hemoglobinuria

disorder

SNOMED 1963002CUI C0024790

Overview

Source: MedlinePlus.gov, National Library of Medicine. Not a substitute for medical advice.

Treatments & Interventions

Ravulizumab

substance

Pegcetacoplan

substance

Signs & Symptoms

Based on Human Phenotype Ontology (HPO) disease-phenotype annotations.

Abnormal erythrocyte enzyme concentration or activity

Always present (100%)HP:0030272

Hemoglobinuria

Very frequent (80-99%)HP:0003641

Hemolytic anaemia

Very frequent (80-99%)HP:0001878

Low number of red blood cells or hemoglobin

Very frequent (80-99%)HP:0001903

Prostration

Very frequent (80-99%)HP:0025406

Blood clot in vein

Frequent (30-79%)HP:0004936

Chest pain

Frequent (30-79%)HP:0100749

CKD

Frequent (30-79%)HP:0012622

Conjunctival icterus

Frequent (30-79%)HP:0032106

Decreased circulating iron concentration

Frequent (30-79%)HP:0040303

Deep venous thrombosis

Frequent (30-79%)HP:0002625

Episodic abdominal pain

Frequent (30-79%)HP:0002574

Erythromelalgia

Frequent (30-79%)HP:0032147

Headache

Frequent (30-79%)HP:0002315

Hemosiderinuria

Frequent (30-79%)HP:0012543

Increased blood urea nitrogen

Frequent (30-79%)HP:0003138

Increased lactate dehydrogenase level

Frequent (30-79%)HP:0025435

Panting

Frequent (30-79%)HP:0002094

Reduced haptoglobin level

Frequent (30-79%)HP:0020181

Reticulocytosis

Frequent (30-79%)HP:0001923

Thromboembolic events

Frequent (30-79%)HP:0001907

Unconjugated hyperbilirubinemia

Frequent (30-79%)HP:0008282

Acute kidney injury

Occasional (5-29%)HP:0001919

Blood clot in artery

Occasional (5-29%)HP:0004420

Blood clot in artery of lung

Occasional (5-29%)HP:0002204

Budd-Chiari syndrome

Occasional (5-29%)HP:0002639

Cerebral vascular events

Occasional (5-29%)HP:0001297

Difficulty getting an erection

Occasional (5-29%)HP:0000802

Erythroid hyperplasia

Occasional (5-29%)HP:0012132

High blood pressure

Occasional (5-29%)HP:0000822

Related Conditions

Anaemia due to intrinsic red cell abnormality(parent)

Quick Facts

SNOMED CT: 1963002
UMLS CUI: C0024790
Fully Specified Name: Paroxysmal nocturnal hemoglobinuria (disorder)
Specialists: 0
Diagnostic Biomarkers: 0
HPO Phenotypes: 30
Known Treatments: 2

Medical Disclaimer

This information is for educational purposes only and does not constitute medical advice, diagnosis, or treatment. Always consult with a qualified healthcare provider regarding any medical condition or treatment plan.

Clinical content is derived from the SNOMED CT clinical ontology and curated medical knowledge graphs.