Substance / Medication

Pegcetacoplan

Overview

Active Ingredient
pegcetacoplan
RxNorm CUI
2557372

Indications

SYFOVRE is indicated for the treatment of geographic atrophy (GA) secondary to age-related macular degeneration (AMD).

Labeler: Apellis Pharmaceuticals, Inc.Updated: 2025-09-16T00:00:00.000ZFull label on DailyMed

Indications & Related Conditions

Conditions associated via SNOMED clinical relationships

Administration & Protocol

Dosing, route, and treatment protocol

Detailed dosage and administration information is available in the full FDA drug label.

View full prescribing information on DailyMed

Monitoring & Follow-Up

Biomarkers relevant to this intervention via related conditions

No monitoring biomarkers have been mapped yet. Biomarker-intervention linkages are derived through related conditions and will expand as the knowledge graph grows.

Research Evidence

Published studies and systematic reviews

Sort:
Visual Acuity and Quality of Life Outcomes With Pegcetacoplan Treatment: A Post Hoc Analysis From the OAKS and DERBY Trials.
Chiang Allen, Davis Matthew, Stevens Warren et al. · Am J Ophthalmol · 2025
PMID: 40449644RCT
Safety and efficacy of pegcetacoplan treatment for cold agglutinin disease and warm antibody autoimmune hemolytic anemia.
Roman Eloy, Fattizzo Bruno, Shum Merrill et al. · Blood · 2025
PMID: 39486046RCT
Trial of Pegcetacoplan in C3 Glomerulopathy and Immune-Complex MPGN.
Fakhouri Fadi, Bomback Andrew S, Ariceta Gema et al. · N Engl J Med · 2025
PMID: 41337715RCT
Disease Activity and Therapeutic Response to Pegcetacoplan for Geographic Atrophy Identified by Deep Learning-Based Analysis of OCT.
Schmidt-Erfurth Ursula, Mai Julia, Reiter Gregor S et al. · Ophthalmology · 2025
PMID: 39151755RCT
Improved Iron Overload with Pegcetacoplan in Eculizumab-Experienced Patients with Paroxysmal Nocturnal Hemoglobinuria.
Shammo Jamile, Hillmen Peter, Blandino Peter et al. · Int J Mol Sci · 2025
PMID: 41155315RCTFull text (PMC)
Pegcetacoplan Treatment and Consensus Features of Geographic Atrophy Over 24 Months.
Fu Dun Jack, Bagga Pallavi, Naik Gunjan et al. · JAMA Ophthalmol · 2024
PMID: 38722644RCTFull text (PMC)
A Cost Effectiveness Analysis of Avacincaptad Pegol for the Treatment of Geographic Atrophy with Comparison to Pegcetacoplan.
Patel Nimesh A, Hoyek Sandra, Al-Khersan Hasenin et al. · Ophthalmol Retina · 2024
PMID: 38777140RCT
Moving toward Individual Treatment Goals with Pegcetacoplan in Patients with PNH and Impaired Bone Marrow Function.
Szer Jeff, Panse Jens, Kulasekararaj Austin et al. · Int J Mol Sci · 2024
PMID: 39201278RCTFull text (PMC)
Pegcetacoplan controls hemolysis in complement inhibitor-naive patients with paroxysmal nocturnal hemoglobinuria.
Wong Raymond Siu Ming, Navarro-Cabrera Juan Ramon, Comia Narcisa Sonia et al. · Blood Adv · 2023
PMID: 36848639RCTFull text (PMC)

Research data from MEDLINE/PubMed

Benefits & Expected Outcomes

Benefits, expected outcomes, efficacy data, and NNT (Number Needed to Treat) are pending physician authorship and evidence review.

Risks & Side Effects

Adverse reaction and safety data for this drug is sourced from the FDA-approved label.

View adverse reactions & drug interactions on DailyMed

Related Symptoms

Symptoms associated with conditions this intervention addresses

No related symptoms have been mapped yet. Symptom linkages are derived through associated conditions.

Alternatives & Comparisons

Alternative treatments, comparison data, and clinical decision support are pending physician authorship.

Medical Disclaimer

This information is for educational purposes only and does not constitute medical advice, diagnosis, or treatment. Always consult with a qualified healthcare provider regarding any medical condition or treatment plan.

Do not start, stop, or change any treatment without consulting your healthcare provider.

Quick Facts

Type
Substance / Medication
Fully Specified Name
Pegcetacoplan (substance)
SNOMED CT
1162412004
UMLS CUI
C5418501
RxNorm CUI
2557372
Labeler
Apellis Pharmaceuticals, Inc.

Clinical Data

This intervention maps to 1 entities in the Ltrl knowledge graph.

1
Conditions
0
Biomarkers
0
Specialists
0
Symptoms

Data is sourced from SNOMED CT, UMLS, and the Ltrl clinical knowledge graph. Content sections marked as pending require physician authorship. Consult a healthcare provider before starting any treatment.