ANA IFA Panel Comprehensive
The ANA IFA Comprehensive Panel evaluates autoimmune activity by detecting antinuclear antibodies and a range of disease-specific autoantibodies, including dsDNA, Sm, Sm/RNP, Scl-70, and Sjögren’s SS-A and SS-B.
What This Test Measures
Biomarkers Included (12)
Click any biomarker for detailed information
This test measures MTHFR, an enzyme critical for processing folate and producing molecules needed for DNA synthesis and methylation. MTHFR enzyme deficiency is a rare inherited metabolic disorder causing severe neurological problems, including intellectual disability, seizures, and movement disorders. Genetic variations (polymorphisms) in the MTHFR gene are common but usually don't cause disease. However, actual enzyme deficiency requires specialized treatment with folinic acid and other supplements. This test is ordered when genetic MTHFR deficiency is suspected based on neurological symptoms or family history.
Progesterone is a hormone produced by the ovaries after ovulation and by the placenta during pregnancy. A urine progesterone test measures metabolites of this hormone to assess reproductive function and confirm ovulation. Abnormally low levels may indicate anovulation (failure to ovulate), luteal phase defect, or hormonal imbalances affecting fertility. This test helps evaluate menstrual irregularities, assess fertility, and monitor pregnancy status. It's particularly useful for tracking ovulation timing and identifying hormonal causes of infertility.
This test detects IgE antibodies against diphenylmethane diisocyanate (MDI), a chemical used in polyurethane manufacturing and foam production. Workers in these industries may develop occupational asthma or allergic sensitization to MDI. IgE antibodies indicate an allergic immune response. Elevated levels suggest isocyanate-induced occupational asthma risk, warranting workplace safety measures and potential job modification.
Hexamethylene diisocyanate (HDI) is an industrial chemical used in paints, coatings, and adhesives. This test detects IgE antibodies to HDI, indicating occupational allergic sensitization. Workers exposed to isocyanates may develop respiratory symptoms, asthma, or skin reactions. A positive IgE result confirms allergic sensitization and helps guide workplace interventions, protective equipment use, or job reassignment to prevent occupational asthma and disease progression.
Vanadium is a trace mineral found in small amounts in the body and food sources. This test measures vanadium levels within red blood cells (RBCs). While vanadium has been studied for potential metabolic effects, routine vanadium testing is not standard clinical practice and is primarily used in specialized research or rare metabolic evaluations.
This test detects IgE antibodies against canary grass (Phalaris arundinacea), a common pollen allergen. IgE antibodies indicate allergic sensitization and immediate allergy risk. Elevated levels suggest canary grass pollen allergy, which may cause seasonal allergic rhinitis, asthma, or other respiratory symptoms during grass pollen season.
This test detects IgE antibodies against toluene diisocyanate (TDI), an industrial chemical used in polyurethane manufacturing and foam production. IgE indicates allergic sensitization to this occupational allergen. Elevated levels suggest occupational asthma or allergic reactions from TDI exposure, primarily affecting workers in manufacturing.
A nidus refers to the central core or nucleus of a kidney stone or other calculus formation. This analysis identifies the composition and mass of the stone's innermost material, which is chemically distinct from outer layers. Understanding the nidus composition helps determine the underlying cause of stone formation—whether due to calcium oxalate, uric acid, infection, or other factors. This information is crucial for preventing recurrent stone formation through diet and lifestyle modifications.
This test detects IgE antibodies to banana, indicating a potential food allergy. Banana allergies can occur as a primary allergy or as part of oral allergy syndrome, where people with certain pollen allergies react to similar proteins in fruits like banana. Symptoms range from mild mouth itching to more severe reactions. IgE-mediated banana allergies are less common than other fruit allergies but can be serious. A positive result helps confirm the allergy and guides dietary choices. Some people may tolerate cooked bananas better than raw ones.
This test detects IgE antibodies against walnut allergens in your blood. Tree nut allergies like walnuts can cause reactions ranging from oral itching and swelling to severe anaphylaxis. A positive result indicates a walnut allergy and suggests caution with other tree nuts due to cross-reactivity. This test helps confirm a suspected allergy and is essential for safe food choices and emergency preparedness, especially since tree nut allergies often persist throughout life.
Nuclear antibodies are proteins your immune system produces that attack the nucleus of your own cells. This test uses immunofluorescence to detect and measure these antibodies in synovial fluid (joint fluid). Elevated levels are commonly associated with autoimmune diseases like lupus, rheumatoid arthritis, and Sjögren's syndrome. A positive result suggests the immune system is attacking the body's own cells.
This category encompasses laboratory test results that have been sent to a specialized reference laboratory for advanced or specialized testing. Reference labs perform complex analyses that are not available at routine hospital or clinic labs, such as genetic testing, specialized microbiology cultures, or complex immunological assays. Results from these tests provide detailed diagnostic information for uncommon or complicated medical conditions.
Included Tests
Individual tests bundled in this panel
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This information is for educational purposes only and does not constitute medical advice, diagnosis, or treatment. Always consult with a qualified healthcare provider regarding any medical condition or treatment plan.
Lab results should be interpreted by a licensed healthcare provider in the context of your complete medical history. Processing times may vary by laboratory. Charges will not be submitted to insurance, Medicare, or Medicaid. Direct-access lab testing is not available in NY, NJ, or RI.
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