Anal fissure

disorder

SNOMED 30037006CUI C0016167

Overview

Source: MedlinePlus.gov, National Library of Medicine. Not a substitute for medical advice.

Treatments & Interventions

Phenylephrine bitartrate

substance

Phenylephrine hydrochloride

substance

Botulinum toxin type A

substance

Phenylephrine

substance

Pramoxine

substance

Pramoxine hydrochloride

substance

Benzocaine

substance

Nitroglycerin

substance

AbobotulinumtoxinA

substance

OnabotulinumtoxinA

substance

IncobotulinumtoxinA

substance

Phenylephrine tannate

substance

Clinical Trials

Total Trials

Recruiting

With Results

Recent Trials

Complex Treatment of a Chronic Anal Fissure

NCT03855046Phase 4Recruiting340 enrolled

Perianal Nerval Block in Proctological Interventions

NCT03405922Phase 4Completed166 enrolled

Efficacy and Safety of Propionibacterium Extract Gel Versus 0.4% Glyceryl Trinitrate Ointment in the Treatment of Chronic Anal Fissure: a Randomised Controlled Trial

NCT05616455Phase 4Completed120 enrolled

Efficacy and Safety of CLIFE1 Gel in Benign Anorectal Surgery

NCT02961855Phase 4Completed120 enrolled

Pain and Bleeding in Subjects With Acute Anal Fissure: Comparative Evaluation of Three Treatments

NCT03355846Phase 4Completed99 enrolled

View all 6 trials on ClinicalTrials.gov

Research Evidence

Peer-reviewed studies linked via MeSH term "Fissure in Ano" from the MEDLINE/PubMed database.

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Effectiveness of combined botulinum toxin and fissurectomy on chronic anal fissures - a systematic review.

[object Object], [object Object], [object Object] et al. · ANZ J Surg · 2025

PMID: 39350497Meta-Analysis

The efficacy of diltiazem, glyceryl trinitrate, nifedipine, minoxidil, and lidocaine for the medical management of anal fissure: a systematic review and network meta-analysis of randomized controlled trials.

[object Object], [object Object], [object Object] et al. · Int J Surg · 2025

PMID: 39878173Meta-AnalysisFull text (PMC)

Efficacy and safety of botulinum toxin injection in the management of chronic symptomatic anal fissure: a systematic review and meta-analysis of randomized controlled trials.

[object Object], [object Object], [object Object] et al. · Tech Coloproctol · 2025

PMID: 39786616Meta-Analysis

Botulinum toxin injection versus lateral internal sphincterotomy for chronic anal fissure: a meta-analysis of randomized control trials.

[object Object], [object Object], [object Object] et al. · Langenbecks Arch Surg · 2024

PMID: 39579232Meta-Analysis

Botulinum toxin as a promising surgical strategy for chronic anal fissure: do the dose and injection site matter? Comparison of doses and injection sites of botulinum toxin for chronic anal fissure: A systematic review and network meta-analysis of randomized controlled trials.

[object Object], [object Object], [object Object] · Int J Surg · 2023

PMID: 36906767Meta-AnalysisFull text (PMC)

Clinical Outcomes of Medical Management Options for Chronic Anal Fissures in a Long-Term Follow-up: Systematic Review and Meta-Analysis.

[object Object], [object Object], [object Object] et al. · Dig Dis · 2023

PMID: 36646066Meta-Analysis

Comparing closed versus open lateral internal sphincterotomy for management of chronic anal fissure: systematic review and meta-analysis of randomised control trials.

[object Object], [object Object] · Sci Rep · 2023

PMID: 38017243Meta-AnalysisFull text (PMC)

Effects of neuromodulation on treatment of recurrent anal fissure: A systematic review.

[object Object], [object Object], [object Object] et al. · Int J Surg · 2022

PMID: 35568308Meta-Analysis

A systematic review and meta-analysis of the efficacy of topical sphincterotomy treatments for anal fissure.

[object Object], [object Object], [object Object] et al. · Int J Colorectal Dis · 2022

PMID: 34608561Meta-Analysis

Comparison of doses and injection sites of botulinum toxin for chronic anal fissure: A systematic review and network meta-analysis of randomized controlled trials.

[object Object], [object Object], [object Object] et al. · Int J Surg · 2022

PMID: 35934283Meta-Analysis

Search all PubMed articles for Anal fissure

Research data from MEDLINE/PubMed

Related Conditions

Acute anal fissure(child)

Chronic anal fissure(child)

Anal fissure and fistula(child)

Congenital anal fissure(child)

Anal disorder(parent)

Anorectal fissure(parent)

Quick Facts

SNOMED CT: 30037006
UMLS CUI: C0016167
Fully Specified Name: Anal fissure (disorder)
Specialists: 0
Diagnostic Biomarkers: 0
Known Treatments: 12
Clinical Trials: 6

Medical Disclaimer

This information is for educational purposes only and does not constitute medical advice, diagnosis, or treatment. Always consult with a qualified healthcare provider regarding any medical condition or treatment plan.

Clinical content is derived from the SNOMED CT clinical ontology and curated medical knowledge graphs.